Results 231 to 240 of about 22,284,815 (342)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Inverse-designed gyrotropic scatterers for non-reciprocal analog computing. [PDF]

Nanophotonics
Hadjiantoni N, Goh H, Hanham SM, Navarro-Cía M, Alù A.   +4 more
europepmc   +1 more source

Advanced Edge Computing Frameworks for Optimizing Data Processing and Latency in IoT Networks

Bhumeka Narra, Dheeraj Varun Kumar Reddy Buddula, Hari Hara Sudheer Patchipulusu, Achuthananda Reddy Polu, Navya Vattikonda, Anuj Gupta   +5 more
openalex   +1 more source

Fault-Resilience of Dissipative Processes for Quantum Computing [PDF]

James Purcell, Abhishek Rajput, Toby S. Cubitt   +2 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Quantum computing and the implementation of precision medicine. [PDF]

NPJ Genom Med
Nassir N, Hashmi MA, Raji KG, Jamalalail B, Maksymowsky A, Scherer SW, Alsheikh-Ali A, Uddin M.   +7 more
europepmc   +1 more source

A different way to formulate computing: Optimal Adiabatic Scaling (OAS) and Processor‐In‐Memory‐and‐Storage (PIMS).

, 2014
Erik P. DeBenedictis
openalex   +1 more source

Fuzzy Logic and Evolutionary Computing in Adaptive Control Systems and Process Engineering [PDF]

Alejandro Maté, Swati Bula Patil, Prema S. Kadam   +2 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Evaluation and optimization of resource matching for perception services in power communication networks. [PDF]

Sci Rep
Wei L, Shang L, Zhang M, Li H, Zhu X.
europepmc   +1 more source