Results 61 to 70 of about 2,580,445 (341)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Machining process parameters optimization using soft computing technique

Journal of Engineering and Applied Science, 2023
This work introduces an approach for optimization machinability measures of power consumption, machining time, and the surface roughness (PMS). This approach is starting with market customer’s demands, passing by optimizing the machinability measures ...
Tarek M. El Hossainy, Yasser Zeyada, Abdallah Abdelkawy   +2 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Engineering a QoS Provider Mechanism for Edge Computing with Deep Reinforcement Learning

, 2019
With the development of new system solutions that integrate traditional cloud computing with the edge/fog computing paradigm, dynamic optimization of service execution has become a challenge due to the edge computing resources being more distributed and ...
Carpio, Francisco, Ferrer, Ana Juan, Jukan, Admela, Sosa, Roman   +3 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Enhanced Reliability for Winding Machine via New Fault Tolerant Control Based on RST-Backstepping Controller

Power Electronics and Drives, 2021
Due to the external disturbances, model uncertainties, strong coupling, and occurred faults, the winding machine presents a great control challenge. In order to deal with these problems, this paper presents the formulation of a novel scheme of fault ...
Haouari Fouad, Messekher Salaheddine, Bali Noureddine, Tadjine Mohamed, Boucherit Mohamed Seghir   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Managing success criteria and success factors in a BPM project: an approach using PRINCE2 and Success Management on the public sector

Cogent Business & Management
The public sector has many challenges when improving business processes. One of those challenges is managing the projects’ success by considering the context and constraints of public management and business process management (BPM).
Nilton Takagi, João Varajão, Thiago Ventura, Darclea Ubialli, Thais Silva   +4 more
doaj   +1 more source

High density mechanical energy storage with carbon nanothread bundle

Nature Communications, 2020
Carbon nanothreads are promising for applications in mechanical energy storage and energy harvesting. Here the authors use large-scale molecular dynamics simulations and continuum elasticity theory to explore mechanical energy storage in carbon ...
Haifei Zhan, Gang Zhang, John M. Bell, Vincent B. C. Tan, Yuantong Gu   +4 more
doaj   +1 more source