Results 131 to 140 of about 5,272,056 (327)

The systems engineering overview and process (from the Systems Engineering Management Guide, 1990) [PDF]

The past several decades have seen the rise of large, highly interactive systems that are on the forward edge of technology. As a result of this growth and the increased usage of digital systems (computers and software), the concept of systems ...

core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Recent advances in process engineering and upcoming applications of metal-organic frameworks. [PDF]

Coord Chem Rev, 2021
Ryu U, Jee S, Rao PC, Shin J, Ko C, Yoon M, Park KS, Choi KM.   +7 more
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Optimization of High‐κ HfO2 Transistor Dielectrics by Atomic Layer Deposition as an Enabler of Novel Thin‐Film Circuits and Sensors

Advanced Physics Research
This study explores the integration of atomic layer deposited (ALD) HfO2 dielectric films with solution‐processed In2O3 semiconductor channel, thin‐film transistors (TFTs) for a silicon chip‐free temperature sensor label. The inclusion of the HfO2 high‐κ
Matin Forouzmehr, Hamed Pourkheirollah, Fabio Leite, Elin Howard, Sunil Kumar Behera, Amit Tewari, Jarmo Laakso, Kimmo Lahtonen, Cesar A. T. Laia, A. Jorge Parola, Phillipe Marrec, Donald Lupo, Paul. R. Berger   +12 more
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Elimination of Escherichia coli in a Packed Column Containing Jujube Seed Kernel Granular Activated Carbon Coated With Silver Nanoparticles (Ag-NPs/GAC)

Journal of Chemistry
This study aims to develop a filter material capable of inhibiting bacterial growth and eliminating microorganisms from filtered water. Granular activated carbon (GAC) was prepared from jujube seed kernels by a chemical activation method whereby the ...
Ngounou M. Kameni, Mengue Nsoe, Esegni V. Amba, Guillaume Kofa, Koungou S. Ndi, Guifo J. Kayem   +5 more
doaj   +1 more source

CONSIDERATION ON THE ROLES OF RURAL ENGINEERING ADMINISTRATION SYSTEM FROM THE PROCESS OF MAKING REGIONAL ORDER IN WATER RESOURCES MANAGEMENT —A CASE OF WATER CONFLICT IN THE OHNO RIVER BASIN, OITA—

, 2020
Hitoshi NINOMIYA, Masahide Horita
openalex   +2 more sources