A Process Framework for Ethically Deploying Artificial Intelligence in Oncology. [PDF]
J Clin Oncol, 2022 Hantel A +5 more
europepmc +1 more source
A process algebra based framework for promise theory
, 2007 We present a process algebra based approach to formalize the interactions of computing devices such as the representation of policies and the resolution of conflicts. As an example we specify how promises may be used in coming to an agreement regarding a
Bergstra, Jan +2 more
core
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Data driven mixed effects modeling of the dual process framework of addiction among individuals with alcohol use disorder. [PDF]
PLoS One, 2023 Everett RA +5 more
europepmc +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Toward a Semiotic Framework for Using Technology in Mathematics Education: The Case of Learning 3D Geometry [PDF]
, 2004 This paper proposes and examines a semiotic framework to inform the use of technology in mathematics education. Semiotics asserts that all cognition is irreducibly triadic, of the nature of a sign, fallible, and thoroughly immersed in a continuing ...
Nason, Rodney, Yeh, Andy
core +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Ageing as a two-phase process: theoretical framework
Frontiers in AgingHuman ageing, along with the ageing of conventional model organisms, is depicted as a continuous and progressive decline of biological capabilities accompanied by an exponentially increasing mortality risk.
Flaminia Zane +5 more
doaj +1 more source
Covid-19 Travel Planner Mobile Application Design with Lean Product Process Framework. [PDF]
Augment Hum Res, 2022 Tavichaiyuth N +4 more
europepmc +1 more source