Results 111 to 120 of about 35,353,269 (300)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Sharing aggregate risks under moral hazard [PDF]
This paper analyzes the efficient design of insurance schemes in the presence of aggregate shocks and moral hazard. The population is divided into groups, the labour force in different sectors for instance.
Gabrielle Demange
core
Jere Nash Interview with Mark Hazard
, 2004 Interview conducted by author Jere Nash with Mark Hazard in the process of writing Mississippi Politics: The Struggle for Power, 1976-2006. Topics covered include Hazard\u27s family and background; Hazard working for U.S. Senator James O.
Nash, Jere, Hazard, Mark
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Process hazard analysis: Proposing a structured procedure based on Multilevel Flow Modelling
, 2023 Process hazard analysis is significant in improving process safety in complex systems. Hazard and operability study (HAZOP) is one of the event-based methods of displaying hazards in the process industry, which can identify a wide range of hazards ...
Wu, Jing +4 more
core
Example process hazard analysis of a Department of Energy water chlorination process [PDF]
, 1993 On February 24, 1992, the Occupational Safety and Health Administration (OSHA) released a revised version of Section 29 Code of Federal Regulations CFR Part 1910 that added Section 1910.119, entitled ``Process Safety Management of Highly Hazardous Chemicals`` (the PSM Rule). Because US Department of Energy (DOE) Orders 5480.4 and 5483.1A prescribe OSHA
openaire +2 more sources
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source