Results 151 to 160 of about 14,248,688 (303)

Quality and process improvement of the multidisciplinary Heart Team meeting using Lean Six Sigma. [PDF]

BMJ Open Qual, 2023
Hoefsmit PC, Schretlen S, Does RJMM, Verouden NJ, Zandbergen HR.   +4 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Quality Improvement Division Annual Report 2016

, 2017
This report provides a high level overview of work completed by the Quality Improvement Division (QID) in 2016. In 2016 QID focused on developing and articulating the Framework for Improving quality that linked together the areas of work in Quality ...
Quality Improvement Division
core  

Process Improvement Before Artificial Intelligence and Automation: Building Trust With the Understand-Transform-Sustain Framework. [PDF]

Mayo Clin Proc Innov Qual Outcomes
Gerbaud AF, Berguido de la Guardia M, Booth SC, Adams L, Cox MD, Hunsinger K, Tan N, Gulden M, Menser T, Reichard R, Dowdy SC, Franco PM.   +11 more
europepmc   +1 more source

Making a Sustainable Difference to People, Processes and Systems: Whole-Systems Approaches to Process Improvement in Health Systems. [PDF]

Int J Environ Res Public Health, 2023
McNamara M, Ward M, Teeling SP.
europepmc   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Process improvement of adeno-associated virus (AAV) production. [PDF]

Front Chem Eng, 2022
Guan JS, Chen K, Si Y, Kim T, Zhou Z, Kim S, Zhou L, Liu XM.   +7 more
europepmc   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Reducing regulated medical waste: A roadmap for process improvement. [PDF]

J Clim Chang Health
Niino CA, Meyer R, John C, Wright K.
europepmc   +1 more source