Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Process improvement of adeno-associated virus (AAV) production. [PDF]
Guan JS +7 more
europepmc +1 more source
Process Improvement: assessing the influence of external intervention [PDF]
This paper presents the findings from a large-scale empirical investigation into the impact of external intervention into business process improvement using a hybrid model of knowledge transfer (KT).
Argyropoulou, Maria +4 more
core
On the Reorganizing Process of Land Improvement Districts and Present Problems in F Prefecture.
Hiroshi Ishii +2 more
openalex +2 more sources
Panarchy Process for Risk Control and Resilience Quantification and Improvement
Ivo Häring +6 more
openalex +2 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The role of histone modifications in transcription regulation upon DNA damage
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Process improvement using telemedicine consultation to prevent unnecessary interfacility transfers for low-severity blunt head trauma. [PDF]
Miles G, Shank C, Quinlan A, Cavender J.
europepmc +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source

