Results 201 to 210 of about 1,503,003 (262)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

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Process improvement

2021
Hospitals must embrace an embedded culture of continuous improvement, rather than use continuous improvement as a superficial fix. The diverse processes, complex quality standards, multiple hierarchies, and hundreds of employees make hospitals complex systems.
Robbin Dick, Robert Agness
  +5 more sources

Approaching Process Improvement

SSRN Electronic Journal, 2020
Process improvement begins with the process view: understanding patient care from the patient's point of view. Organizations must also clearly articulate for themselves how they define operational excellence so that the tradeoffs taken in process improvement can be clearly made. Constructing a process map allows application of powerful analytical tools,
Itai, Gurvich, R Kannan, Mutharasan, Jan Albert, Van Mieghem   +2 more
openaire   +2 more sources

Improving software process improvement

IEEE Software, 2002
Two dichotomies characterize software process improvement efforts and approaches: disciplined versus creative work and procurer risks versus user satisfaction. Based on these perspectives, the authors introduce six theses to illuminate the problems of pursuing SPI.
H. Conradi, A. Fuggetta
openaire   +3 more sources

BUSINESS PROCESS IMPROVEMENT. IMPROVEMENT OF INTERNAL CERTIFICATION PROCESSES

Journal of Engineering, Management and Information Technology, 2023
The purpose of this paper is to expose the processes which are important to run into the organizations. Consumers around the world increasingly demand products and services that are simultaneously good for the economy, for the environment, and for society — the triple bottom line of sustainable growth.
Marjetka Kastner, Mirjana Ivanuša Bezjak, Mojca Babuder   +2 more
openaire   +1 more source