Results 91 to 100 of about 791,980 (219)
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
The Process and Product Innovation Strategies Coordination Model based on Competitor Values Framework [PDF]
بهبود مدیریت, 2011 Innovation literature advises the organizations to follow innovation in different aspects of their activities, especially in their products, as a key factor of competitive advantage.
Mohammad Eskandari +2 more
doaj
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Applying Lean in Process Innovation in Healthcare: The Case of Hip Fracture. [PDF]
Int J Environ Res Public Health, 2020 Morales-Contreras MF +4 more
europepmc +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
DIFFUSION OF INNOVATION PROCESSES IN HIGH-TECH PRODUCTION OF MEDICAL INDUSTRY OF RUSSIA
Sovremennye Issledovaniâ Socialʹnyh Problem, 2013 The concept of diffusion of the innovation process is explained, the theoretical aspects and some scientific works of Schumpeter I., Zavlin P.N., Kazantsev L.K., Mindeli L.E., T. Hegerstrand, E.Rodzhersa are reviewed.
Дарья Витальевна Костина
doaj
Ensuring the Abrasive Jet Machining Efficiency Using a Nozzle with a Perforated Insert
MachinesEjector-cleaning devices for abrasive jet machining have various practical applications. The working nozzle is one of the device’s key elements affecting the treated surface quality.
Vadym Baha +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source