Results 121 to 130 of about 2,983,030 (287)

The influence of innovation on firm size [PDF]

open access: yes
This study puts forward the relevance of investigating the relation between innovation and firm size, acknowledging differences between process innovation and product innovation.
Gerrit de Wit, Niels Bosma
core  

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

The Process and Product Innovation Strategies Coordination Model based on Competitor Values Framework [PDF]

open access: yesبهبود مدیریت, 2011
Innovation literature advises the organizations to follow innovation in different aspects of their activities, especially in their products, as a key factor of competitive advantage.
Mohammad Eskandari   +2 more
doaj  

Innovation and entrepreneurship: structural determinants of competitiveness [PDF]

open access: yes
Innovation and entrepreneurship have become the cornerstone of growth and competitiveness policies. They are both multidimensional, and thus highly complex, concepts.
B. Robert
core  

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

PROCESS INNOVATION: HOLISTIC SCENARIOS TO REDUCE TOTAL LEAD TIME [PDF]

open access: yesAnnals: Series on engineering sciences (Academy of Romanian Scientists), 2015
The globalization of markets requires continuous development of business holistic scenarios to ensure acceptable flexibility to satisfy customers. Continuous improvement of supply chain supposes continuous improvement of materials and products lead time ...
Alin POSTEUCĂ, Miron ZAPCIU
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Approaches to the "fuzzy front end" of innovation [PDF]

open access: yes
In new product development (NPD) unacceptably high failure rates have often been related to insufficiencies during the early development phases. Nevertheless, only little effort is devoted to the early phases, in theory as well as in practice, and ...
Herstatt, Cornelius, Verworn, Birgit
core  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

DIFFUSION OF INNOVATION PROCESSES IN HIGH-TECH PRODUCTION OF MEDICAL INDUSTRY OF RUSSIA

open access: yesSovremennye Issledovaniâ Socialʹnyh Problem, 2013
The concept of diffusion of the innovation process is explained, the theoretical aspects and some scientific works of Schumpeter I., Zavlin P.N., Kazantsev L.K., Mindeli L.E., T. Hegerstrand, E.Rodzhersa are reviewed.
Дарья Витальевна Костина
doaj  

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