Results 41 to 50 of about 11,103,293 (251)

Digitalization of educational organizations as a product- and process-innovation in the data economy: managerial and methodological aspects

Russian Journal of Economics and Law
Objective: to reveal the essence of educational organizations’ digitalization as the implementation of product- and processinnovations in their innovation activity from the managerial viewpoint, including (here) innovation statistics in the data economy.
A. I. Shinkevich, E. Sh. Shaimieva, G. I. Gumerova   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The dynamic links between product and process innovations and productivity for Colombian manufacturing [PDF]

Applied Economic Analysis
Purpose – This paper aims to examine the interrelation between two innovating strategies (product and process) on total factor productivity (TFP) growth and the dynamic linkages between these strategies, for Colombia. The authors first explore whether ex
Juan A. Sanchis Llopis, Juan A. Mañez, Andrés Mauricio Gómez-Sánchez   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

ANALYSIS OF TECHNOLOGICAL INNOVATIONS MANAGEMENT AT RUSSIAN INDUSTRIAL ENTERPRISES: SOURCES OF FINANCING, INNOVATIVE STRATEGY

Russian Journal of Economics and Law, 2012
The article analyzes technological innovations management at Russian industrial enterprises, basing on the study of financial sources of the innovative-technological activity of industrial enterprises, determining the type of innovative strategy of ...
G. I. Gumerova, E. S. Shaymieva
doaj   +2 more sources

Additive friction stir deposition vs. friction surfacing: Comparison of friction stir-based approaches for groove repair of high strength aluminum alloys

Materials & Design
Friction stir-based solid-state layer deposition techniques show considerable potential as additive manufacturing approach but also for repair applications.
Zina Kallien, Victor A. Rojas, Pietro Aspes, Adam N. Swinney, Trevor J. Fleck, J. Brian Jordon, Paul G. Allison, Benjamin Klusemann   +7 more
doaj   +1 more source

Features and critical issues of process innovations

Agathón, 2019
‘Process’ innovations – inclusive (but not substitutive) of similar ‘product’ evolutions (and further factors with which unravel activities of architecture’s production and management) – represent as many ‘countermeasures’ to the challenges posed by the ...
Giorgio Giallocosta
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source