Results 61 to 70 of about 21,952,323 (349)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Environmental innovations and sustainability practices of manufacturing firms in Uganda [PDF]
Asia Pacific Journal of Innovation and EntrepreneurshipPurpose – The purpose of this study is to investigate the pivotal role of environmental innovations in driving sustainability practices within medium and large manufacturing firms operating in Uganda. Design/methodology/approach – Using a cross-sectional
Kassim Alinda +2 more
doaj +1 more source
Invariance principles for linear processes with application to isotonic regression
, 2011 In this paper, we prove maximal inequalities and study the functional central limit theorem for the partial sums of linear processes generated by dependent innovations. Due to the general weights, these processes can exhibit long-range dependence and the
Dedecker, Jérôme +2 more
core +3 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
A socio-technical analytical framework on the EHR-organizational innovation interplay: Insights from a public hospital in Greece [PDF]
, 2015 The healthcare sector globally is confronted with increasing internal and external pressures that urge for a radical reform of health systems' status quo.
Emmanouilidou, Maria
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Explorando Distintos Tipos de Innovación en Micro y Pequeñas Empresas Peruanas
Journal of Technology Management & Innovation, 2013 This article explores the innovation phenomenon, from a multidimensional perspective, in two groups of micro and small enterprises of traditional sectors.
José Isaac Yrigoyen
doaj +1 more source
Value of crowdsourcing in the development process of product innovations [PDF]
Scientific Journal of the Military University of Land Forces, 2018 The article is a theoretical consideration of the possibilities of using crowdsourcing in the development process of product innovations. In the first part of the article the essence of crowdsourcing is shown through the prism of selected elements of the
Anna Szwajlik
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Do Process Innovations Induce Product Ones? [PDF]
We study the relationship between process and product innovations in vertically differentiated duopolies. A process innovation can lead two competing firms to improve the quality of their goods introducing a product innovation.
Maria Rosa Battaggion, Piero Tedeschi
core