Results 71 to 80 of about 251,091 (253)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Protein Polarimetry, Perfected: Specific Rotation Measurement for the Refracto-Polarimetric Detection of Cryptic Protein Denaturation

Biophysica
Protein polarimetry has been evaluated as a simple and straightforward technique to detect the cryptic denaturation of exemplary proteins. The general rules of rotation vs.
Lisa Riedlsperger, Heinz Anderle, Andreas Schwaighofer, Martin Lemmerer   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Hybrid MOF+COF modified PVDF membranes for enhanced microfiltration of pharmaceutical contaminants

Water Resources and Industry
One of the key directions in membrane process development is the exploration of novel materials and the modification of commonly used ones. Designing membrane structures with programmable properties enhances process efficiency and broadens application ...
Daniel Polak, Igor Kogut, Aleksandra Lorek, Emilia Oszajca, Maciej Szwast   +4 more
doaj   +1 more source

Process and Product Innovations: Complements or Substitutes?

, 2010
This paper analyzes rms simultaneous choice in the intensity of process and product innovations, in market with vertical prod- uct di¤erentiation. Considering both monopoly and oligopoly models, we show that di¤erent shocks on the demand and cost ...
Tedeschi, Piero
core  

Schumpeterian innovations, the coase theorem, and sustainable development : a Hong Kong case study of bus innovations

, 2012
The types of innovation considered to be Schumpeterian can be very broad. What is an innovation? According to The Advanced Learner's Dictionary (Hornby, Gatenby, & Wakefield, 1973, p. 545), an innovation is “something new that is introduced.” This covers
Lai, LWC
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Enhancing the Energy Efficiency of a Proton Exchange Membrane Fuel Cell with a Dead-Ended Anode Using a Buffer Tank

Energies
Enhancing energy efficiency is essential for proton exchange membrane fuel cells (PEMFCs) operating in a dead-ended anode (DEA) mode. This study proposes the integration of a buffer tank, positioned between the mass flow meter and the fuel cell, to ...
Trung-Huong Tran, Karthik Kannan, Amornchai Arpornwichanop, Yong-Song Chen   +3 more
doaj   +1 more source

Adoption of Product and Process Innovations in Differentiated [PDF]

The paper examines the effects of the degree of competition on the firms' decision to innovate in differentiated markets. We find that a low (high) degree of product differentiation (competition) weakly supports the introduction of new products.
Pia Weiss
core  

Understanding innovators' experiences of barriers and facilitators in implementation and diffusion of healthcare service innovations: A qualitative study [PDF]

, 2011
This article is made available through the Brunel Open Access Publishing Fund - Copyright @ 2011 Barnett et al.Background: Healthcare service innovations are considered to play a pivotal role in improving organisational efficiency and responding ...
Brooks, L, Konstantina Vasileiou, Brooks Laurence, Djemil Fayika, Young, Terry, Young, T, Julie Barnett, Terry Young, Fayika Djemil, Barnett, J, Young Terry, Vasileiou, Konstantina, Brooks, Laurence, Barnett, Julie, Vasileiou, K, Djemil, F, Laurence Brooks, Barnett Julie, Djemil, Fayika, Vasileiou Konstantina   +19 more
core   +1 more source