Results 91 to 100 of about 11,103,293 (251)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Protection of Innovations [PDF]

This paper proposes a model where firms invest in secrecy to limit technological spillovers accruing to their competitors, in addition to investing in cost-reducing R&D.
Gamal Atallah
core  

Perceptions of innovations: exploring and developing innovation classification [PDF]

, 2003
The capacity to innovate is commonly regarded as a key response mechanism, a critical organisational competence for success, even survival, for organisations operating in turbulent conditions.
Adams, Richard
core   +2 more sources

Enhancing Port Energy Autonomy Through Hybrid Renewables and Optimized Energy Storage Management

Energies
Hybrid renewable energy systems (HRESs) are being incorporated and evaluated within seaports to realize efficiencies, reduce dependence on grid electricity, and reduce operating costs.
Dimitrios Cholidis, Nikolaos Sifakis, Nikolaos Savvakis, George Tsinarakis, Avraam Kartalidis, George Arampatzis   +5 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Scholar-based Innovations in Publishing [PDF]

, 2003
In recent years, a number of innovations have emerged that seek to provide sustainable alternatives to the predominant publishing paradigm. In this presentation, a variety of initiatives that exploit the inherent potential of the Web and other digital ...
McKiernan, Gerry
core   +1 more source

Additive Manufacturing: Alloy Design and Process Innovations. [PDF]

Materials (Basel), 2020
Prashanth KG, Wang Z.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

GOVERNMENT BUDGET IN SYSTEM OF COST RECOVERY ON INNOVATIONS PRODUCTION: VARIATIVE APPROACH

Advanced Engineering Research, 2010
Instruments of financing innovative processes in the aspect of cost refunding on innovations development are considered. Limits and possibilities of the state participation in the system priming reproduction of innovative products in the Russian economy ...
Elena A. MIDLER
doaj