Results 101 to 110 of about 11,103,293 (251)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

GOVERNMENT BUDGET IN SYSTEM OF COST RECOVERY ON INNOVATIONS PRODUCTION: VARIATIVE APPROACH

Вестник Донского государственного технического университета, 2018
Instruments of financing innovative processes in the aspect of cost refunding on innovations development are considered. Limits and possibilities of the state participation in the system priming reproduction of innovative products in the Russian economy ...
Elena A. MIDLER
doaj  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The process engraver's monthly.

Numbering continuous.Mode of access: Internet.Feb.-Aug. 1895, 1899- , Nov. 1903, The Process photogram; Apr. 1896-Feb. 1898, The Process photogram and illustrator (continued as caption title to Nov.
Federation of Master Process Engravers.
core  

Transformative innovations igniting coffee supply chain process efficiency

Journal of Innovation and Entrepreneurship
Despite the geographical advantages of coffee plants and the high economic worth of Indonesian coffee goods, particularly in West Java Province, they have not resulted in significant production yields and economic benefits.
Maya Irjayanti, Anton Mulyono Azis, Susilawati, Andika Rizki Sobari   +3 more
doaj   +1 more source

Special economic zones, gender and innovations: new evidence from an emerging economy

Cogent Business & Management
This paper examines how the gender of CEOs affect product and process innovations at the firm level, focusing on how SEZ features affect the gender-innovations nexus.
Charles Godfred Ackah, Robert Darko Osei, Baah Aye Kusi   +2 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Social Innovations in the Process of System Products Development [PDF]

Journal of Economics and Management, 2015
The article shows the essence of social innovation, its place and role in the development of innovative economy and innovative society. Social innovation is described as an active participation, entrepreneurship and creativity of different social groups ...
Anna Olejniczuk-Merta
doaj