Results 101 to 110 of about 31,124,721 (333)

Orchestrating the spatial planning process: from Business Process Management to 2nd generation Planning Support Systems [PDF]

open access: yes, 2014
Metaplanning can be considered as a necessary step for improving collaboration, transparency and accountability in sustainable and democratic spatial decision-making process.
CAMPAGNA, MICHELE   +2 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

The Management of Process of the Budget Area [PDF]

open access: yes, 2018
The budget area, of the Technical University of Manabí, has an organizational structure that is not coupled with the planning, because it has an organizational complexity according to its technical-administrative dimension, although it complies with all ...
Mora, M. L. (Mayra)   +1 more
core  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Integrating Case-Based Reasoning with Adaptive Process Management [PDF]

open access: yes, 2008
The need for more flexiblity of process-aware information systems (PAIS) has been discussed for several years and different approaches for adaptive process management have emerged.
Pinggera, J.   +4 more
core   +2 more sources

European Code Against Cancer, 5th edition – hormone replacement therapy, other common medical therapies and cancer

open access: yesMolecular Oncology, EarlyView.
The 5th edition of the European Code Against Cancer (ECAC5) contains 14 recommendations on cancer prevention. Here, we update the cancer prevention recommendations regarding the use of hormone replacement therapy (HRT), which is positioned as recommendation number 13 of the ECAC5.
Mangesh A. Thorat   +18 more
wiley   +1 more source

Decision Management Process Improvement Project [PDF]

open access: yes, 2016
A Project Submitted in Partial Fulfillment of the Requirements for the Degree of MASTER OF SCIENCE in Project ManagementIt has become all too common that questions are raised during the execution of a project pertaining to the decisions that were ...
Dahl, Alina
core  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Home - About - Disclaimer - Privacy