Results 121 to 130 of about 30,391,045 (381)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
, 2015 This article reflects on our 2003 article, “Exploitation, Exploration, and Process Management: The Productivity Dilemma Revisited,” which received the Academy of Management Review’s Best Article Award in 2003 and Decade Award in 2013.
Mary J. Benner, M. Tushman
semanticscholar +1 more source
Molecular Oncology, EarlyView.A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul +11 more
wiley +1 more source
Process management of intellectual capital formation
Vìsnik Žitomirsʹkogo Deržavnogo Tehnologìčnogo Unìversitetu: Ekonomìčnì Nauki, 2018 The article deals with the analytical approach to the formation of the structural and logical model of management of intellectual capital of construction enterprises through the application of the process approach.
K.Mamonov, D.Prunenko, O.Uhodnikova
doaj +1 more source
Addressing unforeseen public health risks via the use of sustainable system and process management. [PDF]
Front Public Health, 2023 Zhang Y, Yu Y, Fong PSW, Shen J.
europepmc +1 more source
The functions of visual management [PDF]
, 2009 Visual Management has been evolving and effectively employed in some manufacturing and service organisations for a long time. In order to facilitate a cross-industrial learning process and to advance in detailed research the understanding of how the ...
Koskela, LJ, Tezel, BA, Tzortzopoulos, P
core
Molecular Oncology, EarlyView.Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva +5 more
wiley +1 more source
Retracted: The Influence of PDCA Process Management on the Incidence of Stab Wound and Psychological Anxiety of Nursing Interns. [PDF]
Biomed Res Int, 2023 International BR.
europepmc +1 more source