Results 151 to 160 of about 6,996,748 (368)

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Present-day bureaucratic organization: managerial analysis

Контуры глобальных трансформаций: политика, экономика, право, 2016
The article contains existing approaches to bureaucracy. There were defined 4 main management principles in bureaucratic organization on basis of Max Weber’s “rational bureaucracy” theory.
Dmitry S. Vitashov
doaj  

Development of an integrated and comprehensive clinical trial process management system. [PDF]

BMC Med Inform Decis Mak, 2023
Shen L, Zhai Y, Pan A, Zhao Q, Zhou M, Liu J.   +5 more
europepmc   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Business and management data processing II [PDF]

, 1962
E. S. Page, C. C. Gotlieb
openalex   +1 more source

Integrating Case-Based Reasoning with Adaptive Process Management [PDF]

, 2008
The need for more flexiblity of process-aware information systems (PAIS) has been discussed for several years and different approaches for adaptive process management have emerged.
Pinggera, J., Reichert, M.U., Weber, B., Wild, W., Zugal, S.   +4 more
core   +2 more sources

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Collaborative Framework with Shared Responsibility for Relief Management in Disaster Scenarios [PDF]

arXiv
Disasters instances have been increasing both in frequency and intensity causing the tragic loss of life and making life harder for the survivors. Disaster relief management plays a crucial role in enhancing the lifestyle of disaster victims by managing the disaster impacts.
arxiv  

Contributions of PDM Systems in Organizational Technical Data Management [PDF]

arXiv, 2010
Product Data Management (PDM) claims of producing desktop and web based systems to maintain the organizational data to increase the quality of products by improving the process of development, business process flows, change management, product structure management, project tracking and resource planning.
arxiv  

Business and management data processing I [PDF]

, 1962
Alfred G. Dale
openalex   +1 more source