Results 171 to 180 of about 19,509,703 (356)
Advanced Science, EarlyView.This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu +6 more
wiley +1 more source
A Framework for High-Accuracy Privacy-Preserving Mining
, 2004 To preserve client privacy in the data mining process, a variety of techniques based on random perturbation of data records have been proposed recently.
Agrawal, Shipra, Haritsa, Jayant R.
core +3 more sources
Advanced Science, EarlyView.Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han +6 more
wiley +1 more source
The Microbiota Shapes Central Nervous System Myelination in Early Life
Advanced Science, EarlyView.Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch +13 more
wiley +1 more source
Connexin43 Deficiency Leads to Ventricular Arrhythmias by Reprogramming Proline Metabolism
Advanced Science, EarlyView.The study demonstrated that connexin43 (Cx43) knockout caused arrhythmic phenotype and decreased proline content in vitro and in vivo. Mechanistically, Cx43 interacts with the amino acid transporter SNAT2 (sodium‐dependent neutral amino acid transporter), and its deficiency disrupts proline transport and metabolism.
Hangying Ying +8 more
wiley +1 more source
Detecting Cyber Attacks on Industrial Control Systems using Process Mining
, 2019 D. Brenton Myers
openalex +1 more source
Mechanism‐Driven Screening of Membrane‐Targeting and Pore‐Forming Antimicrobial Peptides
Advanced Science, EarlyView.To combat antibiotic resistance, this study employs mechanism‐driven screening with machine learning to identify pore‐forming antimicrobial peptides from amphibian and human metaproteomes. Seven peptides are validated, showing minimal toxicity and membrane disruption.
Jiaxuan Li +9 more
wiley +1 more source
Exploring Acute Pancreatitis Clinical Pathways Using a Novel Process Mining Method. [PDF]
Healthcare (Basel), 2023 Yang X +5 more
europepmc +1 more source
Species and coenotic composition of phytocoenoses in Jurassic clay dumps of the Callovian layer of the Mikhailovsky Mining and Processing Plant of Kursk Magnetic Anomaly [PDF]
, 2020 Antonina Valentinovna Golovastikova +1 more
openalex +1 more source
Advanced Science, EarlyView.ABSTRACT Precise transgene‐free gene upregulation remains a challenge in crop biotechnology, as conventional enhancers often exceed CRISPR‐mediated knock‐in size constraints and face regulatory hurdles. Here we establish a foundational cross‐species resource of compact transcriptional enhancers developed via STEM‐seq, a high‐throughput screening ...
Qi Yao +14 more
wiley +1 more source