Results 241 to 250 of about 27,406,507 (306)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Posterior estimation of longitudinal variance components from nonlongitudinal data using Bayesian Gaussian process model. [PDF]

Genetics
Arjas A, Leppälä K, Sillanpää MJ.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Treatise on an alternative perspective on the two-process model of sleep regulation. [PDF]

NPJ Biol Timing Sleep
Bes F.
europepmc   +1 more source

Motivating Self-Care and Enhancing Treatment Adherence in Elderly Type 2 Diabetes: An Extended Parallel Process Model Intervention. [PDF]

Nurs Res Pract
Kabusi M, Mahmoodi-Shan GR, Charkazi A, Tatari M.   +3 more
europepmc   +1 more source

Self-Protection Motivation and Its Psychological Construction: A Process Model Distinguishing Two Unique Motivational Orientations. [PDF]

Pers Soc Psychol Rev
Meese WB.
europepmc   +1 more source

The Feasibility and Preliminary Effects of a Stress Process Model-Based Program in Dementia Caregiving (DeCare-SPM) for Family Caregivers: A Mixed-Methods Pilot Study. [PDF]

J Multidiscip Healthc
Wu J, Li X, Liu W, Ma Y, Zhao Q, Xiao M, Wang J.   +6 more
europepmc   +1 more source

Impact of a care process model on outcomes in emergency department patients with atrial fibrillation. [PDF]

Heart Rhythm O2
Ahuja R, Von Bargen M, Klemmer H, Cheng D, Veillet-Chowdhury M, Seto T, Matsuo B, Wong K, Hamele S, Singh D.   +9 more
europepmc   +1 more source

Development and psychometric evaluation of an earthquake risk perception tool in Iran: an application of the extended parallel process model. [PDF]

BMC Psychol
Jahangiry L, Babaie J, Sadr-Mir F, Birgani HR, Gilani N.   +4 more
europepmc   +1 more source