Results 121 to 130 of about 42,397,765 (329)

Finding the optimal way to build an information security system based on Markov chains

Вестник Дагестанского государственного технического университета: Технические науки
Objective. The study examined the main aspects of building an information security system from the point of view of optimizing the resources spent and funds to ensure information security. Method.
A. M. Konakov, I. I. Livshits
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

CREATING A FOUNDATION FOR BUSINESS PROCESS AUTOMATION: A METHODOLOGICAL APPROACH TO STRUCTURING

Економіка та суспільство
Business process automation requires a thoroughly structured foundation to ensure operational efficiency, accuracy, and long-term adaptability. This article introduces a comprehensive methodology for business process declaration, viewed as an essential ...
Ліана Мазник, Павло Ятченко   +1 more
doaj   +1 more source

ANALISIS SISTEM AKUNTANSI PEMERINTAH PUSAT (SAPP) DI KANTOR AKUNTANSI REGIONAL JAKARTA

Jurnal Vokasi Indonesia, 2013
This research is intended to describe Central Government Accounting System (SAPP) implemented by the State Financial Accounting Agency (BAKUN) through The Regional Accounting Office (KAR) and the expected outcomes of Central Government Accounting System.
Titis Wahyuni
doaj   +1 more source

Agarose Cryogels: Production Process Modeling and Structural Characterization. [PDF]

Gels, 2023
Mancino R, Caccavo D, Barba AA, Lamberti G, Biasin A, Cortesi A, Grassi G, Grassi M, Abrami M.   +8 more
europepmc   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Multiscale Process Modeling of Semicrystalline PEEK for Tailored Thermomechanical Properties. [PDF]

ACS Appl Eng Mater, 2023
Kashmari K, Al Mahmud H, Patil SU, Pisani WA, Deshpande P, Maiaru M, Odegard GM.   +6 more
europepmc   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source