Results 161 to 170 of about 13,364,467 (259)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Wood-Plastic Composites: Manufacturing, Rheology and Processing and Process Modeling. [PDF]

Materials (Basel)
Wilczyński K, Buziak K, Wilczyński A.
europepmc   +1 more source

Surgical Process Modeling for Open Spinal Surgeries. [PDF]

Front Surg, 2021
Carrillo F, Esfandiari H, Müller S, von Atzigen M, Massalimova A, Suter D, Laux CJ, Spirig JM, Farshad M, Fürnstahl P.   +9 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Artificial Intelligence in Metal Additive Manufacturing: Applications in Design, Process Modeling, Monitoring, and Quality Optimization. [PDF]

Materials (Basel)
Sustacha J, Uralde V, Rodríguez-Díaz Á, Veiga F.   +3 more
europepmc   +1 more source

Bayesian calibration, process modeling and uncertainty quantification in biotechnology. [PDF]

PLoS Comput Biol, 2022
Helleckes LM, Osthege M, Wiechert W, von Lieres E, Oldiges M.   +4 more
europepmc   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Quantification of retinotopic maps with a Gaussian process modeling. [PDF]

J Vis
Waz S, Wang Y, Lu ZL.
europepmc   +1 more source

Improving Implementation of an Electronic Prescription System for COVID-19 Vaccination in the Czech Republic: Process Modeling Approach. [PDF]

JMIR Form Res, 2023
Berger J, Bruthans J, Kofránek J.
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source