Results 151 to 160 of about 1,558,454 (317)

Modelling and monitoring of resin transfer moulding [PDF]

, 2000
Modelling and monitoring tools appropriate for the resin transfer moulding composites manufacturing route were developed in this study. A simulation of the curing stage of the process based on a finite elements solution of the non-linear heat ...
Skordos, A.A., Skordos, Alexandros A.
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Prescriptive process monitoring: Quo vadis? [PDF]

PeerJ Comput Sci, 2022
Kubrak K, Milani F, Nolte A, Dumas M.
europepmc   +1 more source

A Review of Data-Driven Intelligent Monitoring for Geological Drilling Processes

The exploration and development of resources and energy are fundamental to human survival and development, and geological drilling is a key method for deep resource and energy exploration.
Haipeng Fan, Sheng Du, Cheng Huang, Xian Ma   +3 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Nonlinear Impact Damage Evolution of Charpy Type and Analysis of Its Key Influencing Factors

Chinese Journal of Mechanical Engineering
The current research of Charpy impact mainly focuses on obtaining the ductile brittle transition temperature of materials by experiments. Compared with experiments, numerical simulation can study many problems with harsh conditions.
Jianfeng Mao, Qian Xu, Jiadong Yang, Chi Cao, Dasheng Wang, Fengping Zhong, Mingya Chen   +6 more
doaj   +1 more source

Advances in structural analysis and process monitoring of thermoplastic composite pipes. [PDF]

Heliyon, 2023
Okolie O, Latto J, Faisal N, Jamieson H, Mukherji A, Njuguna J.   +5 more
europepmc   +1 more source

Corrosion State Monitoring Based on Multi-Granularity Synergistic Learning of Acoustic Emission and Electrochemical Noise Signals

Corrosion monitoring is crucial for ensuring the structural integrity of equipment. Acoustic emission (AE) and electrochemical noise (EN) have been proven to be highly effective for the detection of corrosion. Due to the complementary nature of these two
Guangbin Shan, Feng Qiu, Linqi Zhu, Xianglong Meng, Kai Song, Ruiqin Li, Rui Wang, Kang Wang, Xu Chen   +8 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source