Results 171 to 180 of about 4,205,927 (281)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Enhancing Powder Bed Fusion-Laser Beam Process Monitoring: Transfer and Classic Learning Techniques for Convolutional Neural Networks. [PDF]

Materials (Basel)
Sawicki P, Dybała B.
europepmc   +1 more source

Biological Synthesis and Process Monitoring of an Aggregation-Induced Emission Luminogen-Based Fluorescent Polymer. [PDF]

JACS Au, 2022
Liu C, Bian X, Kwok RTK, Lam JWY, Han L, Tang BZ.   +5 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Multisource Heterogeneous Data Fusion-Based Process Monitoring of the Reheating Furnace in Steel Production. [PDF]

ACS Omega
Ban Y, Zhang Y, Wang X, Yang Y, Wu Z.
europepmc   +1 more source

Bioanalytics for Influenza Virus-Like Particle Characterization and Process Monitoring. [PDF]

Front Bioeng Biotechnol, 2022
Carvalho SB, Silva RJS, Sousa MFQ, Peixoto C, Roldão A, Carrondo MJT, Alves PM.   +6 more
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Process Monitoring for Vacuum-Assisted Resin Infusion by Using Carbon Nanotube-Based Sensors. [PDF]

Polymers (Basel)
Shi Y, Wang B, Du K, Liu Y, Kang R, Wang S, Zhang J, Gu Y, Li M.   +8 more
europepmc   +1 more source

Process monitoring for quality - A multiple classifier system for highly unbalanced data. [PDF]

Heliyon, 2021
Escobar CA, Macias D, Morales-Menendez R.   +2 more
europepmc   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source