Results 81 to 90 of about 1,558,454 (317)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Intelligent defect classification system based on deep learning

Advances in Mechanical Engineering, 2018
A fast and intelligent defect classification system for distinguishing defect features is developed in this study. Defect images obtained from an automated optical inspection instrument are first trained utilizing a deep learning approach based on the ...
Ruifang Ye, Chia-Sheng Pan, Ming Chang, Qing Yu   +3 more
doaj   +1 more source

Improved Statistical Pattern Analysis Monitoring for Complex Multivariate Processes Using Empirical Likelihood

, 2020
This article developed an improved statistical pattern analysis (SPA) monitoring strategy for fault detection of complex multivariate processes using empirical likelihood.
Xiaomin Shen, Xin Zhang, Jianwen Shao, Wenhua Chen   +3 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Statistical Process Control Using Control Charts with Variable Parameters

, 2023
An extremely important issue in quality management is monitoring and diagnosing processes, and, subsequently, supervising them using so-called control charts. In typical production processes, charts with constant parameters are commonly used, such as x-R,
Tadeusz Sałaciński, Jarosław Chrzanowski, Tomasz Chmielewski   +2 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Monitoring the Recombinant Adeno-Associated Virus Production using Extended Kalman Filter

, 2022
The recombinant adeno-associated virus (rAAV) is a viral vector technology for gene therapy that is considered the safest and most effective way to repair single-gene abnormalities in non-dividing cells. However, improving the viral titer productivity in
Varun Mehta, Nabil Belacel, Mounia Akassou, Xingge Xu, Amine Kamen, Miodrag Bolic, Alina Venereo-Sanchez, Cristovão Freitas Iglesias   +7 more
core   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Fault Diagnostics Based on the Analysis of Probability Distributions Estimated Using a Particle Filter

Sensors
This paper proposes a monitoring procedure based on characterizing state probability distributions estimated using particle filters. The work highlights what types of information can be obtained during state estimation and how the revealed information ...
András Darányi, János Abonyi
doaj   +1 more source