Results 101 to 110 of about 4,251,197 (303)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Enantioselective maternal transfer of chiral pesticide metabolite o,p’-DDD in zebrafish (Danio rerio): Implications for intergenerational thyroid disruption

Environmental Chemistry and Ecotoxicology
Recent studies show that pesticides can induce intergenerational toxicity, posing threats to wildlife populations. However, the intergenerational effects of chiral pesticide metabolites remain understudied despite their known enantioselective ...
Lili Niu, Honghong Gong, Zhuoye Xue, Xue Li, Kainan Qian, Xinkai Lin, Xiaohui Sun, Jinsong Liu, Chaonan Zhang, Chao Xu, Weiping Liu   +10 more
doaj   +1 more source

A Guide to Evaluating Marine Spatial Plans [PDF]

, 2014
Marine spatial plans are being developed in over 40 countries around the world, to distribute human activities in marine areas more sustainably and achieve ecological, social, and economic objectives.
Charles Ehler
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Effect of Bath ZrO2 Concentration on the Properties of Ni-Co/ZrO2 Coatings Obtained by Electrodeposition

International Journal of Electrochemical Science, 2018
Ni-Co/ZrO2 composite coatings with different ZrO2 contents have been prepared by electrodeposition. The ZrO2 content was controlled by deploying different ZrO2 particle concentrations in the bath. Micrographs, composition, microstructure, micro-hardness,
Sirui Li, Pengfei Ju, Yapeng Zhang, Xiaofeng Zhang, Xuhui Zhao, Yuming Tang, Yu Zuo, Ling Pu   +7 more
doaj   +1 more source

Monitoring and the Risk Governance of Repository Development and Staged Closure:Exploratory Engagement Activity in Three European Countries. [PDF]

, 2013
This report is the product of research activity within the EC Seventh Framework Programme “Monitoring Developments for Safe Repository Operation and Staged Closure” (MoDeRn) Project.
Bergmans, Anne, Elam, Mark, Simmons, Peter, Sundqvist, Goran   +3 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Perinatal exposure to 4-hydroxy-4′-isopropoxydiphenylsulfone alters the adipogenesis in adult mice: A sex-specific study

Ecotoxicology and Environmental Safety
4-hydroxy-4′-isopropoxydiphenylsulfone (BPSIP), a common alternative to bisphenol A (BPA), has been detected in breast milk and across placental barriers. However, the long-term impacts of perinatal exposure to BPSIP on adipogenesis and susceptibility to
Shengnan Zhang, Jiatong Shen, Kaini Hu, Yitong Zhou, Yumeng Wang, Xin Wang, Kashif Hayat, Mingrong Qian   +7 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source