A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia
Advanced Science, EarlyView.A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun +11 more
wiley +1 more source
Structuring integration for patient-centered care: a review-informed ontology-driven modular front-end framework for digital health innovation. [PDF]
Front Digit HealthAmbalavanan R +5 more
europepmc +1 more source
Advanced Science, EarlyView.We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun +5 more
wiley +1 more source
Ontology-aware DNA methylation classification with a curated atlas of human tissues and cell types. [PDF]
Cell Rep MethodsKim M +4 more
europepmc +1 more source
B. F. Skinner and J. J. Gibson III: From the standpoint of process ontology
Takayuki Tanno +2 more
openalex +2 more sources
Advanced Science, EarlyView.This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou +17 more
wiley +1 more source
Business process implementation using an ontology-driven Web service selection algorithm
, 2014 Sophea Chhun +3 more
openalex +1 more source
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
Simultaneous spatial transcriptomics and morphology profiling as tools to explore how microglia change with age. [PDF]
Nat AgingHenze DE +3 more
europepmc +1 more source
Computational analysis of virus-host protein-protein interactions using gene ontology and natural language processing [PDF]
Pınar Cihan +2 more
openalex +1 more source