Results 91 to 100 of about 12,681,044 (293)
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Business Process Optimization (BPO) concerns making optimal operational decisions during process redesign or process execution, including decisions on which resource to assign to which task, how many resources to schedule at which point in time, and when to plan the processing of which case.
openaire +2 more sources
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Applications of process modeling and optimization in biopharmaceutical manufacturing
Ierapetritou, Marianthi G.With the increasing global market demand, prohibitive drug cost, and biosimilars competition, the biopharmaceutical industry is under pressure to speed up the development and manufacturing of biological products.
Ding, Chaoying
core +1 more source
Flux Weakening Strategy Optimization for Five-Phase PM Machine with Concentrated Windings [PDF]
, 2012 The paper applies an Efficient Global Optimization method (EGO) to improve the efficiency, in flux weakening region, of a given 5-phase Permanent Magnet (PM) machine. An optimal control for the four independent currents is thus defined.
JILIN, Gong +3 more
core
Minimization of Water Age in Water Distribution Systems under Uncertain Demand
Engineering ProceedingsMost existing approaches to ensuring water quality in water distribution systems (WDSs) are deterministic, i.e., they do not consider uncertainties, although they may have significant impacts on the water quality.
Kristina Korder +3 more
doaj +1 more source
Experimental Study on Limestone Cohesive Particle Model and Crushing Simulation
Advances in Materials Science and Engineering, 2018 This study investigates the effect of impact velocity and particle size on crushing characteristics. We use a discrete-element method simulation and construct cohesive limestone particles with internal microinterfaces and cracks for impact crushing ...
Huaiying Fang +5 more
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Multi-response optimization of CO2 laser welding process of austenitic stainless steel [PDF]
, 2008 Recently, laser welding of austenitic stainless steel has received great attention in industry, due to its wide spread application in petroleum refinement stations, power plant, pharmaceutical industry and households.
Olabi, Abdul-Ghani +2 more
core +2 more sources