Results 81 to 90 of about 12,681,044 (293)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
In this article, a case study is analysed using an adaptation of a project scheduling problem with multitasking resource restrictions. The objective is to reduce the operational costs of an open-pit mining process that uses mobile surface equipment, by ...
Solano-Charris E.L. +2 more
core +1 more source
Multi-Objective Optimization of an Industrial Isoprene Production Unit by Using Genetic Algorithm Approach [PDF]
, 2005 The present work deals with the multi-objective optimization of an industrial Isoprene production unit by using Genetic Algorithm (GA). The purpose of this plant is to produce high purity Isoprene for obtaining synthetic and thermoplastic rubber from a ...
Xavier Joulia +9 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Hybrid Fuzzy MCDM for Process-Aware Optimization of Agile Scaling in Industrial Software Projects
Scaling Agile in industrial software projects is a process control problem that must balance governance, scalability, and adaptability while keeping decisions auditable.
Issa Atoum +3 more
core +1 more source
Intelligent feature based resource selection and process planning [PDF]
, 2012 Lien vers la version éditeur: https://www.inderscience.com/books/index.php?action=record&rec_id=755&chapNum=3&journalID=1022&year=2010This paper presents an intelligent knowledge-based integrated manufacturing system using the STEP feature-based ...
MARTIN, Patrick +4 more
core
Process optimization for efficient convergence in large optics fabrication
, 2018 Large optic fabrication is a delicate and time consuming process. Obtaining a large prime optic is often in the critical path of a project and poses a serious risk to both the schedule and budget.
Oh, Chang Jin +3 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
International Journal of Chemical Engineering, 2019 In the present study, the experimental design method was used to optimize the preparation conditions of an activated carbon from prickly pear seed cake by phosphoric acid activation.
Y. El Maguana +4 more
doaj +1 more source