Results 211 to 220 of about 14,409,848 (302)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Artificial intelligence-driven study selection in systematic reviews of randomized controlled trials, emulated trials and economic evaluation studies using large language models. [PDF]

PLOS Digit Health
Looareesuwan P, Ponthongmak W, Tansawet A, Ratanatharathorn C, Owasi HUR, McKay GJ, Attia J, Oami T, Thakkinstian A.   +8 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Hybrid African vulture and Aquila optimizer based efficient clustering approach for enhancing network longevity in wireless sensor networks. [PDF]

Sci Rep
Mathankumar M, Thirumoorthi P, Janakiraman S, Rajkanna U.   +3 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Sugammadex for preventIoN oF pOst-operative pulmoNary complIcAtions (SINFONIA): protocol for an embedded mixed-methods process evaluation. [PDF]

BJA Open
Dunn C, Connolly B, Blackwood B, Silversides JA, Emerson LM, SINFONIA investigators.   +5 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Intelligent Circular Polymer Additive Manufacturing: From Recycling Pathways to Lifecycle Engineering. [PDF]

Polymers (Basel)
Silva FJG, Pacheco F, Sebbe NPV, Pedroso A, Pinto AG.   +4 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Polymer-Enabled Additive Manufacturing for Personalized Drug Delivery and Diagnostic Platforms: Materials, Architectures, Quality Control and Clinical Translation. [PDF]

Polymers (Basel)
Pandian P, Sethuraman V, Shukla AK, Nagappan A.   +3 more
europepmc   +1 more source