Results 231 to 240 of about 14,409,848 (302)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

SSEL-CPP: A SHAP-based feature-selection ensemble learning framework identifies molecular properties of cell-penetrating peptides. [PDF]

Protein Sci
Kwon CW, Kwon M, Basith S, Misra S, Jang YE, Lee G.   +5 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Developing and preliminary testing of temporal occlusion decision scenarios in dynamic contexts: a three-step method. [PDF]

Front Psychol
McGuigan B, Andersson L, Holmström S, Johansson A, Lundkvist E.   +4 more
europepmc   +1 more source

Knowledge-Based Feature Selection Substantially Enhances Data-Driven Wastewater Treatment Modeling. [PDF]

Environ Sci Technol
Gu S, Wang S, Qiu R, Li K, Manjeet Singh J, Zhang J, Ni BJ, Waite TD, Ye L, Duan H.   +9 more
europepmc   +1 more source

Assessment of Visual Fatigue Caused by Eye-Controlled Interaction Based on Task Performance and Pupillary Response with GBDT-LR. [PDF]

Sensors (Basel)
Niu H, Zhao Z, Ai M, Yang X, Zhang X, Fang H.   +5 more
europepmc   +1 more source

Lightweight Transformer-based knowledge distillation framework for high-dimensional spatiotemporal radiomics in breast cancer risk prediction. [PDF]

Vis Comput Ind Biomed Art
Huang H, Zhou H, Huang K, Yang J, Ying P, Lai P, Lin Y, Gao Y.   +7 more
europepmc   +1 more source

DFRL-Mol: a dual-stage framework of reinforcement learning for multi-scenario molecule optimization. [PDF]

Brief Bioinform
Wu Z, Zhao P, Li J, Wang Q, Zhang Q, Yu H, Yu Z, Shi JY.   +7 more
europepmc   +1 more source