Results 31 to 40 of about 883,754 (263)
Discovery of Resource Working Calendars from Process Event Log [PDF]
, 2022 openBusiness Process Simulation (BPS) riferisce a tecniche di simulazione dei comportamenti dei processi aziendali che permettono agli analisti di confrontare scenari alternativi e contribuire all'analisi e al miglioramento dei processi aziendali.
PEGORARO, ALESSANDRO
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Criteria for the evaluation of business process simulation tools [PDF]
, 2007 This paper focuses on a process of simulation software packages selection in the context of business process change projects. The paper presents discrete event simulation, its relation to business process modelling and examples of its practical ...
Bosilj-Vuksic, V., Hlupic, V., Ceric, V.
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A Parallel Processing Approach to Dynamic Simulation of Ethylbenzene Process
, 2021 Parallel computing has been developed for many years in chemical process simulation. However, existing research on parallel computing in dynamic simulation cannot take full advantage of computer performance.
Junkai Zhang +3 more
core +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Towards an agile development method for software process simulation
, 2022 S.83-92 : Ill., Lit.Process simulation modeling has been used for various purposes in software engineering. To become even more widely used, in particular in industrial environments, an effective and efficient modeling method is required.
Angkasaputra, N., Pfahl, D.
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FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source