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Pharmaceutical Application of Process Understanding and Optimization Techniques: A Review on the Continuous Twin-Screw Wet Granulation [PDF]

Biomedicines, 2023
Twin-screw wet granulation (TSWG) is a method of continuous pharmaceutical manufacturing and a potential alternative method to batch granulation processes.
Jie Zhao, Geng Tian, Haibin Qu
doaj   +2 more sources

Toward QbD Process Understanding on DNA Vaccine Purification Using Design of Experiment [PDF]

Frontiers in Bioengineering and Biotechnology, 2021
DNA vaccines, the third generation of vaccines, are a promising therapeutic option for many diseases as they offer the customization of their ability on protection and treatment with high stability.
Lalintip Hocharoen, Sarawuth Noppiboon, Panit Kitsubun   +2 more
doaj   +2 more sources

A quality-by-design approach to improve process understanding and optimise the production and quality of CAR-T cells in automated stirred-tank bioreactors [PDF]

Frontiers in Immunology
Ex vivo genetically-modified cellular immunotherapies, such as chimeric antigen receptor T cell (CAR-T) therapies, have generated significant clinical and commercial outcomes due to their unparalleled response rates against relapsed and refractory blood ...
Tiffany Hood, Fern Slingsby, Viktor Sandner, Winfried Geis, Timo Schmidberger, Nicola Bevan, Quentin Vicard, Julia Hengst, Pierre Springuel, Noushin Dianat, Qasim A. Rafiq   +10 more
doaj   +2 more sources

Understanding Is a Process

Frontiers in Systems Neuroscience, 2022
How do we gauge understanding? Tests of understanding, such as Turing's imitation game, are numerous; yet, attempts to achieve a state of understanding are not satisfactory assessments.
Leslie M. Blaha, Mitchell Abrams, Sarah A. Bibyk, Claire Bonial, Beth M. Hartzler, Christopher D. Hsu, Sangeet Khemlani, Jayde King, Robert St. Amant, J. Gregory Trafton, Rachel Wong   +10 more
doaj   +3 more sources

The Influence of Equipment Design and Process Parameters on Granule Breakage in a Semi-Continuous Fluid Bed Dryer after Continuous Twin-Screw Wet Granulation

Pharmaceutics, 2021
The drying unit of a continuous from-powder-to-tablet manufacturing line based on twin-screw granulation (TSG) is a crucial intermediate process step to achieve the desired tablet quality.
Alexander Ryckaert, Michael Ghijs, Christoph Portier, Dejan Djuric, Adrian Funke, Chris Vervaet, Thomas De Beer   +6 more
doaj   +1 more source

Application of I-Optimal Design for Modeling and Optimizing the Operational Parameters of Ibuprofen Granules in Continuous Twin-Screw Wet Granulation

Biomedicines, 2023
The continuous twin-screw wet granulation (TSWG) process was investigated and optimized with prediction-oriented I-optimal designs. The I-optimal designs can not only obtain a precise estimation of the parameters that describe the effect of five input ...
Jie Zhao, Geng Tian, Haibin Qu
doaj   +1 more source

The Challenge of Die Filling in Rotary Presses—A Systematic Study of Material Properties and Process Parameters

Pharmaceutics, 2020
For the efficient and safe production of pharmaceutical tablets, a deep process understanding is of high importance. An essential process step during tableting is the die filling, as it is responsible for a consistent tablet weight and drug content ...
Ann Kathrin Schomberg, Arno Kwade, Jan Henrik Finke   +2 more
doaj   +1 more source

Understanding the Practice Evaluation Process

Journal of the California Dental Association, 2023
Identifying the steps of the practice evaluation process, you must understand the basic information regarding definitions and terms commonly used with practice sales. The questions most asked by doctors who are considering purchasing a practice.
Gene Elizabeth St. Louis
doaj   +1 more source

Later Wittgenstein on Understanding as a Matter of Mind [PDF]

حکمت و فلسفه, 2021
“What is understanding” is an important question in Later Wittgenstein's works. To examine what understanding is and his positive discussion of understanding, Wittgenstein first shows what understanding is not.
Abolfazl Sabramiz
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Building Coalitions: Understanding the Process

EDIS, 2002
This document is FY507, Part 15 of the 16 part series adapted for use in Florida by Elizabeth B. Bolton and Lisa Guion. Reprinted with permission March, 1997. Revised April, 2002.
Ruth M. Conone, Donna Brown, Russell Willis, Elizabeth B. Bolton, Lisa Guion   +4 more
doaj   +5 more sources