Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Impact of the Process Variables on the Yield of Mesenchymal Stromal Cells from Bone Marrow Aspirate Concentrate. [PDF]
Bioengineering (Basel), 2022 Jeyaraman M +11 more
europepmc +1 more source
, 1999 Air pressure amplitude serves as a critical control parameter of periodic pressure solid state fermentation process. Effects of different air pressure amplitudes on cellulase production by Trichoderma viride-SL were investigated. Experiments were carried
Sun, T, Li, ZH, Liu, BH, Liu, DM
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Effect of Formulation and Process Variables on the Stability and Quality Attributes of Digoxin Formulations. [PDF]
Pharmaceuticals (Basel)Shaikh R +7 more
europepmc +1 more source
Performance of TiO2/UV-LED-Based Processes for Degradation of Pharmaceuticals: Effect of Matrix Composition and Process Variables. [PDF]
Nanomaterials (Basel), 2022 Bertagna Silva D +5 more
europepmc +1 more source
The D-optimal design of blocked and split-plot experiments with mixture components. [PDF]
So far, the optimal design of blocked and split-plot experiments involving mixture components has received scant attention. In this paper, an easy method to construct efficient blocked mixture experiments in the presence of fixed and/or random blocks is ...
Goos, Peter, Donev, AN
core
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Relationship Between Personality Style and Diagnostic Characteristics With Therapeutic Process Variables of Adults With Eating Disorders. [PDF]
Clin Psychol PsychotherGiannopoulos E +4 more
europepmc +1 more source