Results 141 to 150 of about 5,079,190 (348)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Process-Oriented Tolerance and Variation Management: Review and Classification

Applied Sciences
In the context of tolerance management, the consideration of manufacturing and assembly processes is becoming increasingly important. The main drivers for this are, above all, short development times and high-quality requirements, leading to tight ...
Philipp Litzenburger, Stefan Goetz, Lennard Margies, Christoph Bode, Rainer Müller, Sandro Wartzack   +5 more
doaj   +1 more source

The Variational Gaussian Process

, 2015
Appears in International Conference on Learning Representations ...
Tran, Dustin, Ranganath, Rajesh, Blei, David M.   +2 more
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

GAN-Based Framework for Unified Estimation of Process-Induced Random Variation in FinFET [PDF]

, 2022
Taeeon Park, Jihwan Kwak, Hongjoon Ahn, Jinwoong Lee, Jaehyuk Lim, Sangho Yu, Changhwan Shin, Taesup Moon   +7 more
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Effect of Process Parameters on Material Removal Rate and Dimensional Variation of Channel Width in Micro-milling of Aluminium Alloy 6063 T6

, 2018
A.R. Shinge, Uday A. Dabade
openalex   +1 more source

Chapter V. Coupled-Channels Variational Method for Nuclear Breakup and Rearrangement Processes [PDF]

, 1986
M. Kawai, M. Kamimura, Kazuo Takesako
openalex   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Lévy processes with jumps governed by lower incomplete gamma subordinator and its variations [PDF]

, 2023
Meena Sanjay Babulal, Sunil Kumar Gauttam, Aditya Maheshwari   +2 more
openalex   +1 more source