ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
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Monocular Visual Measurement System Uncertainty Analysis and One-Step End-End Estimation Upgrade. [PDF]
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How do drivers react to crossing pedestrians at unsignalized roads? A contrast study for naturalistic driving and dummy pedestrian test. [PDF]
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Correction to "Determinants of geographic variation in the incidence of adult nonmalignant meningioma in the United States, 2010-2019". [PDF]
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