Results 121 to 130 of about 7,512,539 (313)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
SPATIAL-TENPORAL CHARACTERISTICS OF INNOVATIVE DEVELOPMENT INSTITUTIONS
Вестник университета, 2019 Spatial and temporal characteristics of the institutions in general, and innovative development in particular are determined primarily by the research objectives, which correspond to different interpretations of the institutions as objects, environments,
B. Yerznkyan
doaj
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Sustainability and Governance in Developing Open Source Projects as Processes of In-Becoming [PDF]
Technology Innovation Management Review, 2013 Sustainability is often thought of as a binary state: an open source project is either sustainable or not. In reality, sustainability is much more complex. What makes this project more sustainable than that one?
Daniel Curto-Millet
doaj
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Ingeniería e Investigación, 2010 La planeación estratégica de sistemas de información (PESI) es el proceso por medio del cual una organización determina el portafolio de aplicaciones de computador para ayudar a lograr sus objetivos de negocios.
Javier Andrés Arias Sanabria +2 more
doaj
Detecting Change-points in Multidimensional Stochastic Processes [PDF]
, 2005 A general test statistic for detecting change-points in multidimensional stochastic processes with unknown parameters is proposed. The test statistic is specialised to the case of detecting changes in sequences of covariance matrices.
Stochastic Processes, Jan G. De Gooijer
core
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source