Results 141 to 150 of about 7,512,539 (313)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

PODUDARNOST STATUSA UČENIKA I STUDENATA OD 7 DO 21 GODINE SA OČEKIVANIM KONSTRUKTIVNIM PROCESIMA [PDF]

open access: yesSport Mont, 2009
The purpose of this work was an identification of actual status of 775 examinees aged 7 – 20 and comparative analysis with expected values according to process model of Bonacin from 2004.
Dobromir Bonacin
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Communication processes and Cultural Practices [PDF]

open access: yes
Creative media are contexts, catalysts and cultural technologies, playing a pivotal role in activating and directing contemporary phenomena that take place in our society. Communication processes and Cultural Practices book series meet the perspective of
R. Nardone
core  

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

The process of coopetitive strategy: a case study of microbreweries in Porto Alegre / O processo de estratégia coopetitiva: um estudo de caso de microcervejarias em Porto Alegre

open access: yesRAM. Revista de Administração Mackenzie, 2018
Purpose: The study presents a dynamic and complex procedural experience performed by small microbreweries in a cluster in Porto Alegre, Brazil. Thus, this article aims to establish theoretical propositions about coopetition strategies in this context ...
Jefferson M. Monticelli   +2 more
doaj  

Scaling fed-batch and perfusion antibody production processes in geometrically dissimilar stirred bioreactors [PDF]

open access: yes
Modern production processes for biopharmaceuticals often work with very high cell densities. Moreover, there is a trend towards moving from fed-batch to continuous perfusion processes; a development that is influencing the requirements for bioreactor ...
Ott, Vivian   +7 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Formation of microelement composition of soils of Stavropol krai under the influence of waterlogging processes

open access: yesНаука. Инновации. Технологии
The object of the study was the hydromorphic soils of the Tashlyansky landscape of ravine forest-steppes, identified in the Stavropol Krai. The radial geochemical structure of differentiation of gross contents of Zn, Cu, Pb and Cd in the profile of ...
T. V. Degtyareva
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

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