Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Optical memory disks in optical information processing [PDF]
, 1990 We describe the use of optical memory disks as elements in optical information processing architectures. The optical disk is an optical memory devicew ith a storage capacity approaching 1010b its which is naturally suited to parallel access.
Kobayashi, Seiji +3 more
core
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Binary-Weighted Neural Networks Using FeRAM Array for Low-Power AI Computing
NanomaterialsArtificial intelligence (AI) has become ubiquitous in modern computing systems, from high-performance data centers to resource-constrained edge devices.
Seung-Myeong Cho +5 more
doaj +1 more source
Stronger memory representation after memory reinstatement during retrieval in the human hippocampus
NeuroImage, 2022 Memory retrieval allows us to reinstate previously encoded information but is also considered to contribute to memory enhancement. Retrieval-induced enhancement may involve processing to strengthen memory traces, but neural processing beyond ...
Joonyoung Kang +2 more
doaj +1 more source
Processing of regular and irregular past tense morphology in highly proficient second language learners of English: a self-paced reading study [PDF]
, 2012 Dual-system models suggest that English past tense morphology involves two processing routes: rule application for regular verbs and memory retrieval for irregular verbs (Pinker, 1999).
Marinis, Theodoros, Pliatsikas, Christos
core +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Understanding acceptability judgments: Additivity and working memory effects [PDF]
, 2010 Linguists build theories of grammar based largely on acceptability contrasts. But these contrasts can reflect grammatical constraints and/or constraints on language processing.
Hofmeister, Philip +2 more
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Optimizing Memory Efficiency for Convolution Kernels on Kepler GPUs
, 2017 Convolution is a fundamental operation in many applications, such as computer vision, natural language processing, image processing, etc. Recent successes of convolutional neural networks in various deep learning applications put even higher demand on ...
Chen, Danny Z. +3 more
core +1 more source