Results 61 to 70 of about 1,824,046 (280)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

A New Memory-Processing Unit Model Based on Spiking Neural P Systems with Dendritic and Synaptic Behavior for Kronecker Matrix–Matrix Multiplication

open access: yesMathematics
Currently, Kronecker Matrix–Matrix Multiplication play a crucial role in many advanced applications across science and engineering, such as Quantum Computing (Tensor Representation of Quantum States, Quantum Gate Construction), Machine Learning and Data ...
Luis Garcia   +6 more
doaj   +1 more source

Awake, Offline Processing during Associative Learning. [PDF]

open access: yesPLoS ONE, 2016
Offline processing has been shown to strengthen memory traces and enhance learning in the absence of conscious rehearsal or awareness. Here we evaluate whether a brief, two-minute offline processing period can boost associative learning and test a memory
James K Bursley   +3 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Effect of the recall time of autobiographical memory on conscious memory processing and automatic memory processing

open access: yesJournal of Human Environmental Studies, 2016
In this study, I investigated the effect of the recall time of autobiographical memory on conscious and automatic memory processes. Two-second and six-second recall time conditions were used as experimental variables in two different experiments.
Takashi Horiuchi
doaj   +1 more source

Photon echo quantum RAM integration in quantum computer

open access: yes, 2012
We have analyzed an efficient integration of the multi-qubit echo quantum memory into the quantum computer scheme on the atomic resonant ensembles in quantum electrodynamics cavity.
Andrianov, Sergey N., Moiseev, Sergey A.
core   +1 more source

Persistence pays off: Paying Attention to What the LSTM Gating Mechanism Persists [PDF]

open access: yes, 2018
Language Models (LMs) are important components in several Natural Language Processing systems. Recurrent Neural Network LMs composed of LSTM units, especially those augmented with an external memory, have achieved state-of-the-art results. However, these
Kelleher, John D., Salton, Giancarlo D.
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Episodic memory impairment in children and adolescents at risk for schizophrenia: A role for context processing

open access: yesSchizophrenia Research: Cognition, 2022
People with schizophrenia experience episodic memory impairments that have been theorized to reflect deficits in processing context (e.g., spatio-temporal features tied to a specific event). Although past research has reported episodic memory impairments
Aslıhan İmamoğlu   +6 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

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