Results 181 to 190 of about 552,845 (263)

In an older-age vascular cohort, carotid stenosis is associated with processing speed and executive function cognitive deficits, which correlate with p-tau217. [PDF]

Alzheimers Dement
Zahra S, French SR, Arias JC, Ally M, Wiskoski H, Escareno C, Heitkamp E, Vazquez F, Hillis M, Culwell G, Ainapurapu K, Howell CM, Johnson K, Karakay D, Rayasam K, Taylor L, Kraemer C, Leon L, Berman S, Yanquez F, Balderman J, Sabat J, Hung O, Lucas L, Bedrick EJ, Vitali F, Mushtaq R, Altbach M, Trouard TP, Bilgin A, Reiman EM, Alexander GE, Weinkauf CC.   +32 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Abdominal myosteatosis is associated with lower processing speed in a multiethnic cohort of older adults. [PDF]

Arch Gerontol Geriatr
McNeish BL, Miljkovic I, Allison MA, Hughes T, Nasrallah I, Terkpertey E, Rosano C.   +6 more
europepmc   +2 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Daily fluctuations in sleep duration and quality affect next-day processing speed performance in young and older adults: an intensive longitudinal everyday life study over 21 days. [PDF]

Sleep
Schwarz J, Freidle M, van Leeuwen W, Silfverling J, Åkerstedt T, Kecklund G.   +5 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Effects of music advertised to support focus on mood and processing speed. [PDF]

PLoS One
Orpella J, Bowling DL, Tomaino C, Ripollés P.   +3 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Development of the KeyStrokes test: An online neuropsychological assessment for attention, processing speed and executive function. [PDF]

J Neuropsychol
Lopez M, Fulton J, Kristinsson H, Kim S, Stuart E, Chen P, Thomas A, Hussey-Zommers M, Roy R, Kapoor A, Conrad A.   +10 more
europepmc   +1 more source