Results 61 to 70 of about 149,980,641 (289)
In vehicle systems, the suspension is fundamental in achieving acceptable levels of ride comfort, while ensuring ride safety. Semi-active suspensions allow changing the suspension damping to prioritize different performance metrics.
C. Steven Diaz-Choque +5 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Emotion-aware computing can recognize, interpret, process, and simulate human affects. These programs in this area are compute-intensive applications, so they need to be executed in parallel.
Bin Liu +4 more
doaj +1 more source
Catnap: A Backoff Scheme for Kernel Spinlocks in Many-Core Systems
As the number of cores equipped in a system grows, the impact of the spinlock waiting inside the operating system (OS) kernel on the performance and energy efficiency of a system worsens.
Youngjoo Woo +3 more
doaj +1 more source
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Transforming urban water governance through social (triple‐loop) learning
The sustainable development of cities is threatened by a worldwide water crisis. Improved social learning is urgently needed to transform urban water governance and make it more integrated and adaptive.
Å. Johannessen +6 more
semanticscholar +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
After our 2022 seminar with Marc Porée, and our 2023 seminar with Jeremy Elprin on Keats, Loop is proud to present the 2024 agrégation seminar: Claire Vial and Agnès Blandeau: On Sir Gawain and the Green Knight (text and film) Amélie Ducroux : On T.S ...
The LOOP team
core +1 more source
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source

