Results 51 to 60 of about 149,980,641 (289)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Eletrônica de PotênciaCom o grande avanço da utilização de veículos elétricos no mundo, devido ao alto nível de concorrência e com a busca da diminuição dos impactos ambientais que os veículos à combustíveis fósseis trazem, existe um crescimento na tentativa de aumentar a ...
João Batista Viana Neto +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Reinforced Model Predictive Guidance and Control for Spacecraft Proximity Operations
AerospaceAn increased level of autonomy is attractive above all in the framework of proximity operations, and researchers are focusing more and more on artificial intelligence techniques to improve spacecraft’s capabilities in these scenarios.
Lorenzo Capra +2 more
doaj +1 more source
IEEE Access, 2021 This paper proposes an artificial intelligence integrated (AI) fractional order robust control for a DFIG based wind energy conversion system. To reduce the chattering phenomena in the excitation signal, fuzzy system is employed for the adaptive ...
Nasim Ullah +4 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Loop is delighted and honoured to announce that poet and playwright Adam Wyeth, who lives and works in Dublin, is as of June 2024 a patron of Loop. We look forward to continuing our conversation with Adam, begun at the excellent 2024 SAES Congress at ...
The LOOP team
core +1 more source
Sophie Doulut, "The Ivory Horse"
, 2023 One day I rode a magnificent ivory horse It took me up high into the sky Galloping as fast as it could, Bolting from one cloud to the other, And I finally landed Onto another soil, A foreign kingdom Where strange people Spoke a ...
The LOOP team
core