Results 51 to 60 of about 15,198 (259)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Toward Emotion-Aware Computing: A Loop Selection Approach Based on Machine Learning for Speculative Multithreading

IEEE Access, 2017
Emotion-aware computing can recognize, interpret, process, and simulate human affects. These programs in this area are compute-intensive applications, so they need to be executed in parallel.
Bin Liu, Jinrong He, Yaojun Geng, Lvwen Huang, Shuqin Li   +4 more
doaj   +1 more source

Catnap: A Backoff Scheme for Kernel Spinlocks in Many-Core Systems

IEEE Access, 2020
As the number of cores equipped in a system grows, the impact of the spinlock waiting inside the operating system (OS) kernel on the performance and energy efficiency of a system worsens.
Youngjoo Woo, Sunghun Kim, Cheolgi Kim, Euiseong Seo   +3 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Evaluation of Effects and Effectiveness of Various α and β Angulations for Three Different Loop Made of Stainless Steel Arch Wires – A FEM Study [PDF]

Journal of Clinical and Diagnostic Research, 2014
Introduction: Evaluations on retraction loop designs have been limited to describe the force systems applied to the buccal surfaces of the tooth that can be in different planes resulting undesirable effects, needing corrective action in future.
Supradeep Kumar Kamisetty, Raghuveer N, Rajavikram N, Chakrapani N, Dwaragesh, Praven   +5 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A Generic Actuator Management Solution for Space Applications Based on Convex Optimization

Aerospace
This paper addresses a common challenge in space systems: how to effectively manage multiple actuators under demanding mission conditions. We introduce a flexible, optimization-based algorithm designed to dispatch control commands among a set of ...
Jesús Ramírez, Joost Veenman, Ilario Cantiello, Valentin Preda   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Real-Time Processor-in-Loop Investigation of a Modified Non-Linear State Observer Using Sliding Modes for Speed Sensorless Induction Motor Drive in Electric Vehicles

Energies, 2020
Tracking performance and stability play a major role in observer design for speed estimation purpose in motor drives used in vehicles. It is all the more prevalent at lower speed ranges.
Mohan Krishna Srinivasan, Febin Daya John Lionel, Umashankar Subramaniam, Frede Blaabjerg, Rajvikram Madurai Elavarasan, G. M. Shafiullah, Irfan Khan, Sanjeevikumar Padmanaban   +7 more
doaj   +1 more source