Results 131 to 140 of about 16,132 (297)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Achieving Fairness in Generalized Processor Sharing for Network Switches

, 2008
In Generalized Processor Sharing (GPS), the goal of the scheduler is to maximize the processor utilization, while maintaining a rate guarantee and fairness in the bandwidth allocation to each input stream according to the quality of service (QoS ...
Raymond Yim Natasha, Vahid Tarokh, H. T. Kung, Natasha Devroye, Raymond Yim   +4 more
core  

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Physiological signal analysis and open science using the Julia language and associated software

Frontiers in Network Physiology
In this mini review, we propose the use of the Julia programming language and its software as a strong candidate for reproducible, efficient, and sustainable physiological signal analysis. First, we highlight available software and Julia communities that
George Datseris, Jacob S. Zelko, Jacob S. Zelko   +2 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Processor Sharing Systems With Random Capacity Demands [PDF]

, 2011
We discuss processor sharing queueing systems with non-homogeneous demands. This non-homogenity means that each demand (independently of others) has some random capacity and its length (or amount of work for its service) generally depends on the capacity.
Tikhonenko, O.
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Sojourn times in non-homogeneous QBD processes with processor sharing [PDF]

, 1999
We study sojourn times of customers in a processor sharing model with a service rate that varies over time, depending on the number of customers and on the state of a random environment.
Núñez Queija, R. (Rudesindo), Núñez Queija, Rudesindo, Núñez Queija, R.   +2 more
core  

A Processor-Sharing Scheduling Strategy for NFV Nodes

Journal of Electrical and Computer Engineering, 2016
Giuseppe Faraci, Alfio Lombardo, Giovanni Schembra   +2 more
doaj   +1 more source