Results 61 to 70 of about 16,132 (297)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The fluid limit of a heavily loaded processor sharing queue [PDF]
, 2002 Consider a single server queue with renewal arrivals and i.i.d. service times in which the server operates under a processor sharing service discipline.
Puha, A.L. +2 more
core +1 more source
Tongxin xuebao, 2007 In order to get exact bounds problems encountered in networking with self-similar input traffic,a fractal regu-lator was introduced into the ingress of a generalized processor sharing（GPS） system for regulating the self-similar traf-fic,and a model was ...
ZHANG Lian-ming1 +3 more
doaj +2 more sources
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Scheduling for Heavy-Tailed and Light-Tailed Workloads in Queueing Systems [PDF]
, 2012 In much of classical queueing theory, workloads are assumed to be light-tailed, with job sizes being described using exponential or phase type distributions. However, over the past two decades, studies have shown that several real-world workloads exhibit
Nair, Jayakrishnan U.
core +1 more source
Towards a Process Algebra for Shared Processors
Electronic Notes in Theoretical Computer Science, 2002 AbstractWe present initial work on a timed process algebra that models sharing of processor resources allowing preemption at arbitrary points in time. This enables us to model both the functional and the timely behaviour of concurrent processes executed on a single processor.
Mikael Buchholtz +2 more
openaire +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Design Space Exploration of HW Accelerators and Network Infrastructure for FPGA-Based MPSoC
IEEE AccessSupercomputing systems are increasingly reliant on heterogeneous Multiprocessors System on-Chip (MPSoCs), merging multiple processors and hardware accelerators (HWAcc) on the same die to achieve power and performance needs.
Bouthaina Dammak +2 more
doaj +1 more source
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
A Game-Theoretic Analysis of Shard-Based Permissionless Blockchains
IEEE Access, 2018 Low transaction throughput and poor scalability are significant issues in public blockchain consensus protocols, such as Bitcoins. Recent research efforts in this direction have proposed shard-based consensus protocols where the key idea is to split the ...
Mohammad Hossein Manshaei +3 more
doaj +1 more source