Results 21 to 30 of about 1,945 (89)

Personalized‐Context‐Aware Age Gap: A New Multi‐Omics Measurement Based on Age‐Enhanced Model AOE‐Net for Aging Acceleration and Chronic Disease Risk Prediction

Aging Cell, Volume 25, Issue 6, June 2026.
Addressing systemic biases in traditional aging clocks, we introduce PAAG, a context‐aware multi‐omics metric derived from the pre‐trained AOE‐Net. PAAG accurately captures localized aging acceleration, demonstrating superior predictive power for chronic disease risks and clinical outcomes across diverse aging populations.
Feng‐Ao Wang, Tao Zeng, Chunchun Yuan, Hongyu Wang, Yule Yu, Enjin Deng, Yao Wang, Jiangxun Ji, Jiarui Cui, Dezhi Tang, Ruikun He, Yongjun Wang, Yixue Li   +12 more
wiley   +1 more source

Pharmacological inhibition of hydroxysteroid 11‐beta dehydrogenase type 1 (11‐βHSD1) after myocardial infarction preserves cardiac function in a translational mini‐pig model

British Journal of Pharmacology, Volume 183, Issue 10, Page 2236-2255, May 2026.
Abstract Background and Purpose Plasma glucocorticoids increase acutely after MI, thereafter tissue levels are amplified selectively within cells expressing 11‐ßhydroxysteroid dehydrogenase type 1 (11‐ßHSD1) that regenerates active glucocorticoids from circulating metabolites.
Sara Al Disi, Raimondo Ascione, Shazia Khan, Thomas Johnson, Eva Sammut, Vito Domenico Bruno, Daniel Baz Lopez, Carol‐Anne James, Joanna Simpson, Natalie Z. Homer, Michael Millar, Trisha Singh, Alex von Kreigsheim, Nick L. Mills, Brian R. Walker, Ruth Andrew, Scott P. Webster, Andrew Whittaker, Adrian Freeman, Gillian A. Gray   +19 more
wiley   +1 more source

Tooth Decay Promotes Senescence in Dental Pulp Stem Cells, Modifying Their Biological and Proteomic Profiles

Journal of Cellular Physiology, Volume 241, Issue 4, April 2026.
ABSTRACT Dental caries is a prevalent oral health problem that significantly reduces an individual's quality of life; although, it can be effectively managed through restorative treatments. Even in cases where the caries does not reach the pulp, released microbial products from the lesion can still penetrate the pulp chamber, potentially inducing ...
Sebahat Melike Durukan, Mustafa Burak Acar, Banu Çiçek Tez, Ahmet Şimşek, Sura Hilal Ahmed Al‐Sammarrie, Zeynep Günaydın, Melis Güzel, Başak Bilge Süer, Şerife Ayaz Güner, Hüseyin Güner, Nicola Alessio, Kemal Erdem Başaran, Zeynep Burçin Gönen, Servet Özcan   +13 more
wiley   +1 more source

Anti‐Photoaging Effects and Potential Molecular Mechanisms of Ergothioneine‐Derived‐Ganoderma lucidum on UVB‐Irradiated Skin

Food Frontiers, Volume 7, Issue 2, March 2026.
Anti‐photoaging effects of Ganoderma lucidum‐derived ergothioneine in UVB‐irradiated HaCaT cells and skin photoaging mice. ABSTRACT The increasing incidence of skin photoaging associated with enhanced ultraviolet (UV) exposure highlights the need for effective preventive and therapeutic interventions.
Zihao Zong, Zhenhao Li, Ming Yin, Yuanhang Yao, Ben Niu, Huizhi Chen, Ruiling Liu, Jing Xu, Chaoyi Shen, Hangjun Chen, Lijun You, Weijie Wu, Haiyan Gao   +12 more
wiley   +1 more source

Uncovering the role of genetic polymorphisms in cervical insufficiency

International Journal of Gynecology &Obstetrics, Volume 172, Issue 3, Page 1335-1341, March 2026.
Pathways and genes implicated in CI pathogenesis. Abstract Cervical insufficiency (CI) is characterized by spontaneous dilation of the cervix in the absence of painful uterine contractions in the mid‐trimester, leading to premature delivery. It is responsible for up to 20% of second trimester pregnancy losses, mostly <24 weeks.
Kallirhoe Kalinderi, Michail Kalinderis, Maria Chatzidimitriou, Liana Fidani   +3 more
wiley   +1 more source

P53 Inhibition Diminishes IGSF9 Gene Activity to Promote DNA Repair and Exacerbate the Progression of Colon Cancer

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 1, January 2026.
Highlights of the Study: “P53 Inhibition Diminishes IGSF9 Gene Activity to Promote DNA Repair and Exacerbate Progression of Colon Cancer” ABSTRACT Colon cancer (CC) is a malignancy with high global incidence and mortality, and elucidating its underlying molecular mechanisms is critical for improving prognostic assessment and therapeutic strategies.
Huan‐yu Zhang, Dan Tian, Wan‐fu Zhang, Ying‐hui Zhang, Jia‐li Feng, Juan Sheng, Xue‐qin Shang   +6 more
wiley   +1 more source

A guide to building the matrisome interactome: from computational predictions to experimental validation

The FEBS Journal, Volume 293, Issue 1, Page 42-70, January 2026.
This guide proposes a roadmap combining state‐of‐the‐art computational and experimental approaches (including biophysical, biochemical, and imaging techniques) to identify, characterize, and contextualize extracellular matrix (ECM) protein interactions.
Leanna Leverton, Amanpreet Kaur Bains, Ikram Isa, Sylvie Ricard‐Blum, Alexandra Naba   +4 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

New lens on congenital mild bone fragility: a novel Col1a1 knockout mouse model for osteogenesis imperfecta type 1. [PDF]

J Bone Miner Res
Zhytnik L, Ventura L, Sclocco A, Verhage M, Bakker AD, Shim JH, Beaino W, Pereira PM, Hoogeland ME, Heine VM, Maas H, Jaspers RT, Niehoff A, Zaucke F, de Waard V, Eekhoff EMW, Micha D.   +16 more
europepmc   +1 more source

Proteome of the testicular cell-conditioned medium supports germ cell differentiation <i>in vitro</i>. [PDF]

J Adv Vet Anim Res
Prasetyaningtyas WE, Karja NWK, Agungpriyono S, Adnyane IKM, Mohamad K, Fahrudin M.   +5 more
europepmc   +1 more source