Results 131 to 140 of about 967 (262)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Anaesthetic practice and mortality in Scotland compared to England from 1847 to 1914. [PDF]

Anaesth Intensive Care
McKenzie AG.
europepmc   +1 more source

Measuring judiciarization of people with mental illnesses. [PDF]

Crime Law Soc Change, 2022
Mikhaylova O, Naumova J.
europepmc   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Enhanced recovery following neck of femur fractures - improving outcomes : a survey of current perioperative practice. [PDF]

Bone Jt Open
See A, Taylor LA, Rollins KE, Hewson DW, Gordon AL, Duckworth AD, Griffin XL, Ollivere BJ.   +7 more
europepmc   +1 more source

[Artisanal Surgery in the Early 17th Century. The Practice Journal of a Barber-Surgeon in Münster]. [PDF]

NTM, 2023
Stolberg M.
europepmc   +1 more source

Mapping the “Supply–Demand–Flow” of Ecosystem Services for Ecosystem Management in China

Advanced Science, EarlyView.
This study develops a “supply–demand–flow” framework clarifies how ecosystem services move between regions by distinguishing potential and actual supply and demand. Using integrated biophysical–socioeconomic modeling, nine services in China were mapped.
Yikun Zhang, Yadong Yang, Yongsheng Wang, Guirui Yu   +3 more
wiley   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Death literacy: A document analysis review of the United Kingdom's four countries' policies. [PDF]

Palliat Care Soc Pract
Holland-Hart D, Rogerson J, Edwards M.
europepmc   +1 more source

Study protocol for enhanced CJD surveillance in the 65+ years population group in Scotland: an observational neuropathological screening study of banked brain tissue donations for evidence of prion disease. [PDF]

BMJ Open, 2019
Peden AH, Kanguru L, Ritchie DL, Smith C, Molesworth AM.   +4 more
europepmc   +1 more source