Results 141 to 150 of about 592,784 (368)

Inspectorate Supervision in Applying Competitive Principles in Managing Procurement of Goods / Services in Government of North Sulawesi Province [PDF]

open access: yes, 2018
This paper examines the supervision of the Inspectorate on the application of the principle of competitiveness in the management of government goods/services procurement. This research was conducted at the North Sulawesi Provincial Government.
Pakasi, N. C. (Novrabella)
core  

Conjugated Lithocholic Acid Activates Hepatic TGR5 to Promote Lipotoxicity and MASLD‐MASH Transition by Disrupting Carnitine Biosynthesis

open access: yesAdvanced Science, EarlyView.
Takeda G protein‐coupled receptor 5 (TGR5) serves as a central regulator in the metabolic dysfunction‐associated steatotic liver disease (MASLD)/metabolic dysfunction‐associated steatohepatitis (MASH) transition via conjugated lithocholic acid (LCA). Mechanistically, TGR5 orchestrates lipotoxicity‐induced cell death through its interaction with CD36 ...
Senlin Lian   +10 more
wiley   +1 more source

Mas Signaling Potentiates Neutrophil Extracellular Traps Formation Induced by Endothelial Cells Derived S1P in Mice with Acute Liver Failure

open access: yesAdvanced Science, EarlyView.
In mice challenged with lipopolysaccharide/D‐galactosamine (L/G), Mas signaling increased SHP2 in hepatic Col4a1+ endothelial cells, inhibiting farnesoid X receptor (FXR), potentially due to enterogenic deoxycholic acid. This inhibition activates sphingosine‐1‐phosphate‐induced Raf/MEK/ERK signaling in Cldn1+CD177+ neutrophils, causing neutrophil ...
Bo Yang   +11 more
wiley   +1 more source

Truthful Multi-unit Procurements with Budgets [PDF]

open access: yesarXiv, 2014
We study procurement games where each seller supplies multiple units of his item, with a cost per unit known only to him. The buyer can purchase any number of units from each seller, values different combinations of the items differently, and has a budget for his total payment.
arxiv  

Artificial Cornea Substitute Based on Hydrogel Skeletons with Natural Stromal Hierarchical Structure and Extracellular Matrix for Sutureless Transplantation

open access: yesAdvanced Science, EarlyView.
Humanized corneal stroma‐like adhesive patches (HCSPs) are developed for lamellar keratoplasty and corneal perforation repair. HCSPs exhibit histological, optical, and biomechanical characteristics similar to those of the natural cornea, with improved wet tissue adhesion, anti‐degradation, and anti‐swelling capabilities compared to conventional tissue ...
Long Zhao   +9 more
wiley   +1 more source

Generation of Construction Scheduling through Machine Learning and BIM: A Blueprint

open access: yesBuildings
Recent advancements in machine learning (ML) applications have set the stage for the development of autonomous construction project scheduling systems.
Mazen A. Al-Sinan   +2 more
doaj   +1 more source

The impact of procurement methods on delivering environmentally sensitive buildings [PDF]

open access: yes, 2007
In the UK, new building regulations (‘Part L2006’) to reduce energy consumption and carbon dioxide emissions within the built environment came into force in 2006.
Greenwood, David, Hamza, Neveen
core  

What Can 240,000 New Credit Transactions Tell Us About the Impact of NGEU Funds? [PDF]

open access: yesarXiv
Using a panel data local projections model and controlling for firm characteristics, procurement bid attributes, and macroeconomic conditions, the study estimates the dynamic effects of procurement awards on new lending, a more precise measure than the change in the stock of credit.
arxiv  

Optimal Resource Procurement and the Price of Causality [PDF]

open access: yesarXiv, 2019
This paper studies the problem of procuring diverse resources in a forward market to cover a set $\bf{E}$ of uncertain demand signals $\bf{e}$. We consider two scenarios: (a) $\bf{e}$ is revealed all at once by an oracle (b) $\bf{e}$ reveals itself causally. Each scenario induces an optimal procurement cost. The ratio between these two costs is defined
arxiv  

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