Results 181 to 190 of about 66,274 (284)

Prodromal symptoms of rheumatoid arthritis in a primary care database: variation by ethnicity and socioeconomic status

, 2023
d’Elia A, Baranskaya A, Haroon S, Hammond B, Adderley NJ, Nirantharakumar K, Chandan JS, Falahee M, Raza K.   +8 more
europepmc   +1 more source

Predicting Long‐Term Depression Progression in Parkinson's Disease: A Machine‐Learning Survival Analysis and Risk Score

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
We developed and internally validated a machine learning–based survival model for predicting long‐term progression of dPD. Supported by SHAP analysis, the model identified that depressive symptom severity, cognitive impairment, and autonomic dysfunction were the main key clinical predictors for dPD progression.
Defu Liu, Chong Qi, Jiansong Huang, Hutao Xie, Yutong Zhuang, Quan Zhang, Xuemin Zhao, Tianqi Hu, Guofan Qin, Yue Lu, Xin Zhang, Sizhe Li, Mingyu Yang, Jianguo Zhang, Yin Jiang   +14 more
wiley   +1 more source

The Brain‐Gut Axis in Parkinson's Disease Pathology

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Exposure to environmental toxins induces gut dysbiosis, increases intestinal epithelial barrier permeability, immune activation, and oxidative stress, promoting α‐syn misfolding and propagation. Brainstem DMV neurons exhibit α‐syn pathology, dysregulating neuronal excitability and vagal control of GI functions.
Kudret Selin Ozkaya, Kirsteen N. Browning   +1 more
wiley   +1 more source

Positive Reframing of Psychosis Risk is Perceived as Less Frightening and Stigmatising Than Negative Framing by Adolescents With and Without Prodromal Symptoms: An Experimental Simulated Feedback Study. [PDF]

Early Interv Psychiatry
Sol-Nottes Y, Saqer S, Roe D, Mendlovic S, Nasser A, Koren D.   +5 more
europepmc   +1 more source

Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
1. Astrocytes are central integrators of neural circuit function through tripartite synapse modulation and neurovascular coupling. 2. Dysregulation of glutamate/GABA homeostasis and neuroinflammation represents shared mechanisms across diverse neuropsychiatric disorders. 3.
Xinyu Liu, Xinyue Zhou, Ruotong Meng, Yanxi Chen, You Chen, Blake Highet, Maurice Curtis, Bernhard Hirt, Shunying Yu, Jin Zhou, Linya You   +10 more
wiley   +1 more source

Demographic, physical and mental health assessments in the adolescent brain and cognitive development study: Rationale and description [PDF]

, 2018
Barch, Deanna M, et al,
core   +1 more source

Dynamic Alterations of Functional Systems in Alzheimer's Disease: A Co‐Activation Pattern Analysis

Human Brain Mapping, Volume 47, Issue 5, 1 April 2026.
State 3 exhibited significantly reduced persistence and resilience in both MCI and AD compared to CU. Individuals with MCI and AD showed reduced transition probability from State 2 to State 5 and decreased self‐transitions in State 3. Graph theoretical results corresponded well to the findings of the above CAP analysis.
Pan Wang, Mengfan Xue, Yingyin Mao, Chunyan Wang, Xing Yao, Bharat B. Biswal   +5 more
wiley   +1 more source

Deep learning of wrist accelerometry from UK Biobank data identifies early movement signatures of knee osteoarthritis up to 5 years before diagnosis

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 34, Issue 4, Page 1524-1533, April 2026.
Abstract Purpose This study aims to test whether week‐long wrist accelerometry combined with deep learning can (i) distinguish healthy individuals from people with knee osteoarthritis (KOA), (ii) separate prodromal KOA from established KOA, and (iii) identify individuals who will receive a KOA diagnosis within 5 years.
Ricardo Smits Serena, Michael T. Hirschmann, Georg Matziolis, Rüdiger von Eisenhart‐Rothe, Daniel Rueckert, Florian Hinterwimmer, Christina Valle   +6 more
wiley   +1 more source

Therapeutic Impact of Caffeic Acid Phenethyl Ester and Acyclovir Combination on Human Gingival Fibroblasts (HGF‐1) Infected With Herpes Simplex Type 1 ICP0

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
ABSTRACT Herpes simplex virus Type 1 (HSV‐1) is a prevalent infectious agent globally, often causing oral infections like gingivostomatitis. The ICP0 protein of HSV‐1 exacerbates infection severity by inhibiting antiviral responses. Our study explored how combinations of CAPE (caffeic acid phenethyl ester) and acyclovir influenced immune responses in ...
Merve Sen, Sefa Celik
wiley   +1 more source

Long prodromal symptoms of neuroleptic malignant syndrome in patient with intellectual developmental disorder-A case report. [PDF]

Neuropsychopharmacol Rep
Sadati S, Elyasi F, Shyasi Z, Rouhanizadeh B.   +3 more
europepmc   +1 more source