Results 71 to 80 of about 66,274 (284)

The Dynamics of Neurofilament Light Chain in Spinal Muscular Atrophy

Annals of Neurology, EarlyView.
Objective Newborn screening (NBS) for spinal muscular atrophy (SMA) facilitates early diagnosis and treatment for affected individuals. However, fluid biomarkers that provide early insights into disease activity and outcomes in a neonatal cohort and those unable to access (due to reimbursement criteria) or deferring immediate treatment are lacking ...
Arlene D'Silva, Karen Herbert, Lakshmi Balaji, Jia Mei He, Tejaswi Kandula, Hugo A. Sampaio, Hooi‐Ling Teoh, Esther Tantsis, Jihee Sohn, Nancy Briggs, Nickson Ning, Matthew C. Kiernan, Didu S. Kariyawasam, Michelle A. Farrar   +13 more
wiley   +1 more source

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Depression Is Associated With Constipation in Patients With Parkinson's Disease

Frontiers in Neurology, 2020
Objective: Constipation is one of the most frequent non-motor symptoms (NMS) in Parkinson's disease (PD), causing great disturbance to patients. The present study investigated the prevalence and the clinical features of constipation in patients with PD ...
Qin Xiao-ling, Chen Gang, Lu Bo, Li Zai-li, Liu Xue-kui, Li Xue, Shi Ming-yu, Du Yin-zhen, Chen Xu, Gao Dian-shuai   +9 more
doaj   +1 more source

Bisphosphonate-related bilateral atypical femoral fractures : be aware and beware [PDF]

, 2011
Although bisphosphonates have a well established therapeutic role in the prevention of osteoporosis-related fractures, several reports published over the past 5-6 years suggest a possible causative relationship between long-term use of bisphosphonates ...
Cassar-Pullicino, Victor N., Depasquale, Ruben, Matthews, Claire   +2 more
core  

Altered white matter microstructure is associated with social cognition and psychotic symptoms in 22q11.2 microdeletion syndrome. [PDF]

, 2014
22q11.2 Microdeletion Syndrome (22q11DS) is a highly penetrant genetic mutation associated with a significantly increased risk for psychosis. Aberrant neurodevelopment may lead to inappropriate neural circuit formation and cerebral dysconnectivity in ...
Bearden, Carrie E, Chow, Carolyn, Jalbrzikowski, Maria, Karlsgodt, Katherine H, Senturk, Damla, Thompson, Paul M, Villalon-Reina, Julio E   +6 more
core   +3 more sources

Prodromal Symptoms and Relapse Prevention in Schizophrenia [PDF]

Schizophrenia Bulletin, 1995
The value of monitoring for prodromal symptoms in patients with schizophrenia has been questioned by some investigators who point out that their positive predictive value, sensitivity, and specificity can be low in relation to relapse. This article focuses on methodological and conceptual issues which should be considered in evaluating the usefulness ...
M I, Herz, J S, Lamberti
openaire   +2 more sources

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

Neural correlates of executive function and working memory in the 'at risk mental state' [PDF]

Background and Aims: People with ‘prodromal’ symptoms have a very high risk of developing psychosis. We used functional MRI to examine the neurocognitive basis of this vulnerability.
Brammer, M. J. (Mick J.), Bramon, Elvira, Broome, Matthew R., Chitnis, X., Fusar-Poli, Paolo, Johns, Louise C., Matthiasson, P. (Pall), McGuire, Philip, Tabraham, Paul, Valmaggia, Lucia, Williams, S. C. R. (Steven C. R.), Woolley, J. B. (James B.)   +11 more
core   +1 more source

Digital diagnostics, biomarkers and therapeutics in an evolving healthcare system: From promise to practice

British Journal of Clinical Pharmacology, EarlyView.
Abstract Health care is shifting towards a digital‐guided system, integrating digital diagnostics, biomarkers and therapeutics in many care pathways. However, despite rapid technological advancement and preliminary adoption accelerated by the COVID‐19 pandemic, a significant implementation gap persists. This narrative review explores the causes of this
Mees H. P. Stoop, Gertjan J. A. Driessen, Adam F. Cohen, Matthijs D. Kruizinga   +3 more
wiley   +1 more source

Migraine and Epilepsy: Infantile Onset

Pediatric Neurology Briefs, 1991
The coexistence of classical migraine, visual phenomena and seizures and occipital spike-wave complexes in the EEG are reported in 14 children from the Department of Neurological Sciences, University La Sapienza, Rome, Italy.
J Gordon Millichap
doaj   +1 more source